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Fundamental examination about the prevention / treatment of digestive organs disease by Tre foil peptide

Tre箔肽预防/治疗消化器官疾病的基础研究

基本信息

批准号：
17590673
负责人：
HIRAISHI Hideyuki
金额：
$ 2.18万
依托单位：
Dokkyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590673/
关键词：
TFF gastrointestinal mucosa peptic ulcer appearance adjustment

项目摘要

This research is a production life and is secreted, and has aimed to examine the possibility of a clinical application of tray foil peptide (TFF) that has a strong digestive tube mucous membrane protection action with the digestive tube mucous membrane cuticle. We performed the analysis that took clinical application into consideration of TFF inducer and examined in particular the various reasons child who raised endogenous TFF expression. For the human, it is PPARγ ; Because it is only a human TFF2 gene that the PPAR response area is admitted in the TFF2 gene upstream array, PPARγ though Rigand had been found inducing the appearance of TFF2 in the stomach mucous membrane epithelial cell ; The possibility that the unbridgeable gulf is caused in the result in the human and the animal experiment model was thought about the effect of Rigand of the stomach mucous membrane protection. Because it was known that estrogen played TFF1 appearance a center role in other cell systems such as the breast cancer cells about TFF1 that appeared high by the gastric mucosa with TFF2, a detailed examination was done about the influence of estrogen on the TFF1 appearance in the stomach. As a result, estrogen's not influencing the TFF1 appearance at all though estrogen receptor (ER) appeared in the stomach mucous membrane epithelial cell (chiefly ERβ) became clear. Moreover, NE-κB ; The influence that the Cigna ring of the inflammation stimulation for which B is used exerts on the TFF appearance is examined, and the appearance level of TFF1 is TNF-α It had been found to rise with an inflammatory cytokine. In addition, because treatment with Ricombinant TFF peptide in in vivo or the attempt of the TFF gene introduction treatment was scheduled, the animal experiment model's like TNBS cause colitis model etc. preliminary examinations were done.

本研究是一项产生性分泌性研究，旨在探讨具有较强消化管粘膜保护作用的托箔肽(TFF)与消化管粘膜角质层联合应用于临床的可能性。我们进行了考虑TFF诱导剂临床应用的分析，并特别检查了内源性TFF表达升高的各种原因。对于人类来说，它是PPARγ；由于PPAR反应区被接纳在TFF2基因的上游阵列中，PPARγ虽然被发现诱导TFF2在胃粘膜上皮细胞中的出现，但在人和动物实验模型中造成不可逾越鸿沟的可能性被认为是配体对胃粘膜的保护作用。由于已知雌激素在其他细胞系统中起着核心作用，如TFF1周围的乳腺癌细胞在TFF2作用下出现在胃粘膜上，因此我们对雌激素对TFF1在胃中出现的影响进行了详细的研究。结果表明，虽然胃粘膜上皮细胞(主要是ER-β)出现雌激素受体(ER)，但雌激素对TFF1的出现无明显影响。此外，还检测了使用B的炎症刺激的CignA环对κ外观的影响，其外观水平为肿瘤坏死因子-α，已发现随着炎症细胞因子的增加而升高。此外，由于体内应用重组TFF多肽治疗或TFF基因导入治疗的尝试已排期，对类似TNBS致结肠炎模型等动物实验模型进行了初步检测。