A new correction method combined attenuation correction using a difference of intrinsic dual-energy in 201T1C1 SPECT

我们设计了一种新的校正方法，该方法结合了利用低能量发射（71 keV）和高能量发射（167 keV）之间的本征双能差进行衰减校正和利用三能窗（TEW）方法进行康普顿散射校正（71 keV），这是因为增强了^ TlCl（^ Tl）中的本征双能差<201><201>，分别计算了71 keV和167 keV能量窗下获得的SPECT数据的衰减系数比和计数比。在2个不同位置（前（ANT）和下（INF））将具有相同厚度的缺损插入心肌体模的内表面。使用<201>我们用于患者的相同方案，用13 T1进行心肌灌注SPECT研究。无衰减散射（A（-）S（-））、仅散射（A（-）S（+））和衰减散射（A（+）S）重建图像 关于我们 （+））校正的结果表明，71 keV/167 keV的合适衰减系数比和计数比分别为2.277和5。在正常心肌模体中，INF壁经衰减散射（A（+）S（+））校正后得到改善，心肌壁整体均匀;在ANT和INF缺损壁模体中，除缺损壁外，示踪剂分布均匀，所有缺损均清晰可见。对已知或可疑冠心病患者，通过技术可清楚地分辨出病变区域，提高了对冠心病的检出率，提出了一种新的校正方法，即在71 keV下，利用固有双能量差进行衰减校正和利用三能量窗（TEW）方法进行康普顿散射校正相结合的方法，可用于~ <201>1 T1心肌灌注SPECT检查。这可以减少衰减和散射伪影，并且允许对患有已知或疑似CAD的患者进行更准确的评估。少

We devised a new correction method that combined attenuation correction using a difference of intrinsic dual-energy between lower energy emissions (71keV) and higher energy emissions (167keV) without transmission scan and Compton scatter correction using triple-energy window (TEW) method for 71keV because of enhancing a difference of intrinsic dual-energy in ^<201>TlCl (^<201>Tl), and applied to cardiac phantom and myocardial perfusion SPECT studies.Attenuation coefficients ratio and counts ratio for 71keV/167keV were calculated from SPECT data acquired by energy window of 71keV and 167keV, respectively. Defects with the same thickness were inserted on the inner surface of a myocardial phantom at 2 difference locations: anterior (ANT) and inferior (INF). The myocardial perfusion SPECT studies was performed with ^<201>Tl using the same protocol that we use for patients. The images reconstructed by non-attenuation-scatter (A(-)S(-)), only scatter (A(-)S(+)) and attenuation-scatter (A(+)S … More (+)) correction were compared by visual and quantitative analysis, respectively.The adequate attenuation coefficients ratio and counts ratio for 71keV/167keV were 2.277 and 5, respectively. In the normal myocardial phantom, the INF wall was improved by attenuation-scatter (A(+)S(+)) correction, and the whole of the myocardial wall was uniform.In the ANT and INF defect wall phantom, the tracer distribution except defect wall were uniform, and the all defects were clearly detected. In patients with known or suspected CAD, defect regions were clearly discriminated by technique, the detectability for CAD was improved.It is suggested that a new correction method that combined attenuation correction using a difference of intrinsic dual-energy and Compton scatter correction using triple-energy window (TEW) method for 71keV is useful in ^<201>Tl myocardial perfusion SPECT studies. This may reduce both of attenuation and scatter artifacts, and allow the more accurate assessment of patients with known or suspected CAD. Less