A Study of a Quantification of Organs Perfusion with Animal Model Using Nuclear Medicine Technique : Factor of Absorption and Scatter on Gamma-Ray

这篇文章报道了二重奏和对该活动的一小部分精确意图，可以从肝脏和阴道射精中吸取教训，与myocardial uptake进行交互。要研究如何精确地反映图像的追踪器在myocardium中提取，作为基本的实验来测试对肝脏和普通追踪的影响。（除了噬菌体）的活动被从肝脏转移到技术中的myocardium图像-99m myocardium渗透追踪器，我们管理D199 m ye D1 Tc-四氟氰胺（以下， Tetrofosmin）将正常大鼠与伽马摄像机获得的测量值进行比较，并与有机体提取后的实际调查值进行比较。方法：五、十、十五、三十、四十、四十五、六十、九十和120分钟后，三十三只老鼠被测量了。对myocardium、lung、liver、duodenum、小直觉、rectum和血液的累积比率被评估为t的百分比。 ... More he injected dose per gram of tissue （%ID/g）。The accumulated rates for each organ with the planar imaging （PI） were assessed as a percentage of the injected dose per pixel （%ID/pixel） establishing regions of interest （ROIs） in each organ。每个器官的累积比率，PI到WC比率和心脏到器官的比率计算由PI和WC比较。结果：30分钟前，心脏随WC增加的累积率（1.671% ± 0.306%），注射后和次序下降。在另一方面，注射后15分钟内，PI的累积率达到峰值（1.814% ± 0.518%）。在早期阶段，两者在10分钟内有明显的差异（PI/WC比率：约1.6次）。注射后的肺累积率为15分钟最大值（0.870% ± 0.312%）。累积率与PI，如何显示最大值为10分钟（1.139% ± 0.376%），累积率的变化在10分钟后难以识别。对鳄鱼的累积速率从5分钟（0.768% ± 0.193%）到30分钟（0.692% ± 0.273%）的有标记的变化，而退化的趋势则显示出缓慢的变化。在另一方面，PI的累积率比WC高得多，在整个WC中，在10分钟（PI/WC比率：约3.3次）和15分钟（PI/WC比率：约2.3次）内表现出较高的价值。二烯和上小睾丸的累积速率在10分钟内达到最大值（1.228% ± 0.602%，2.245% ± 1.936%），注射后接近达到90%，而D199 m D1 Tc-四氟素是二烯丰富的。结论：每个器官的累积比率与PI显示出比WC更高的比率。两者之间的差异，特别是在注射后的早期阶段更强。PI对心脏的累积速率显示出比WC在10分钟的显著性更高。来自肝脏、二进制和小直觉的康普顿散射的干扰被认为是这些原因之一。Less（低）

It's reported that the duodenum and the small intestine of the activity excreted from the liver and gallbladder can lead to interference with the myocardial uptake. To study how precisely images reflect tracer uptake in a myocardium, as fundamental experiment to examine the influence that accumulation of the liver and alimentary tract (except esophagus) of the activity excreted from the liver gave to the myocardium image in the technetium-99m myocardium perfusion tracer, we administered ィイD199mィエD1Tc-tetrofosmin (following, Tetrofosmin) to a normal rat and compared with measured value obtained by a gamma camera and an actual survey value after the organs extraction. Methods : Thirty-three rats were measured for 5, 10, 15, 30, 45, 60, 90 and 120min after the administration of Tetrofosmin. The accumulated rates for the myocardium, the lung, the liver, the duodenum, the small intestine, the rectum and the blood with a well-type scintillation counter (WC) were assessed as a percentage of t … More he injected dose per gram of tissue (%ID/g). The accumulated rates for each organ with the planar imaging (PI) were assessed as a percentage of the injected dose per pixel (%ID/pixel) establishing regions of interest (ROIs) in each organ. The accumulated rates for each organ, the PI-to-WC ratio and the heart-to-organ ratios calculated by PI and WC were compared. Results : The accumulated rate for the heart with WC increased until 30 min (1.671%±0.306%) after the injection, and subsequently decreased. On the other hand, peak of the accumulated rate with PI was shown at 15 min (1.814%±0.518%) after the injection. Particularly a difference of both was higher in 10 min (PI/WC ratio : about 1.6 times) of the early phase. The accumulated rate for the lung with WC was maximum at 15 min (0.870%±0.312%) after the injection. The accumulated rate with PI, however, showed the maximum value at 10 min (1.139%±0.376%), and a variation of the accumulated rate was hardly recognized 10 min later. The accumulated rate for the liver with WC was hardly shown a marked variance from 5min (0.768%±0.193%) to 30min (0.692%±0.273%), and a tendency of decrease was showed slowly. On the other hand, the accumulated rate with PI was more highly than that with WC in the whole, and high values were showed in 10 min (PI/WC ratio : about 3.3 times) and 15 min (PI/WC ratio : about 2.3 times) in particular. The accumulated rate for the duodenum and the upper small intestine was maximum in 10 min (1.228%±0.602%, 2.245%±1.936%) after the injection, and approximately 90% of ィイD199mィエD1Tc-tetrofosmin were the duodenum excrements. Conclusion : The accumulated rates for each organ with PI were showed higher than that with WC. The difference of both, particularly, was stronger in early phase after the injection. The accumulated rate for the heart with PI was shown significant higher than that with WC at 10 min. The interference of Compton scatter from the liver, duodenum and small intestine was suggested as one of these causes. Less