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Research of significance of AKT for the radioresistant mechanisms in normal and malignant tissue

AKT对正常和恶性组织放射抵抗机制的意义研究

基本信息

批准号：
17591268
负责人：
OKAMOTO Yoshiaki
金额：
$ 2.24万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591268/
关键词：
AKT NF-KappaB Radiosensitivity Radioresistance p53

项目摘要

Significance of AKT in the radioresistant mechanism has not been clarified. In this study, Free radical mediated AKT activation and NF-kappa B activation were closely related to the radioresistance in both normal and malignant cells. Especially, Pelicano and Sasaki have reported that mitochondrial respiratory function communicated with AKT activation through free radical, and the communication led to the invasiveness of the tumor or chemosensitivity.Demizu and Okamoto have reported that effectiveness of cisplatin-based concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma, and clinical outcomes of the treatment as a preliminary report. In the present study, we have found there are certain percentage of patients who experienced their poor outcomes. Moreover, we are now investigating that the relationships between resistance to the anticancer treatment and the AKT activation, as well as p53, NF-kappa B.Ejima and Okamoto have reported that outcomes of MALT lymphoma of the orbita in the journal of Radiotherapy and Oncology. In the study, prognostic factors and adverse effects were clarified from the analysis, in the same time. For this disease, prognostic factors have not been determined. Therefore, candidates for molecular mechanisms of radioresistance, such as AKT, p53 BCL-10, were also assessed. Those results were now preparing for another submission.Thus, the significance of AKT in the radioresistant mechanism were investigated in the multiple situation. In vitro study, and clinical investigation were performed, leading to the fact that AKT was one of the important candidate for molecular mechanisms of intracellular radioresistance.

AKT在放射耐药机制中的意义尚未明确。在本研究中，自由基介导的AKT活化和NF-kappa B活化与正常和恶性细胞的放射耐药密切相关。特别是Pelicano和Sasaki报道了线粒体呼吸功能通过自由基与AKT激活进行沟通，这种沟通导致肿瘤的侵袭性或化疗敏感性。Demizu和Okamoto报道了以顺铂为基础的同步放化疗在鼻咽癌患者中的有效性，以及该治疗的临床结果作为初步报告。在目前的研究中，我们发现有一定比例的患者经历了他们的不良结果。此外，我们现在正在研究对抗癌治疗的耐药性与AKT激活之间的关系，以及p53， NF-kappa B.Ejima和Okamoto在《放射治疗与肿瘤学》杂志上报道了眼眶MALT淋巴瘤的结果。在研究中，从分析中明确了预后因素和不良反应。对于这种疾病，预后因素尚未确定。因此，我们还评估了候选的辐射耐药分子机制，如AKT、p53 BCL-10。这些结果现在正准备提交另一份报告。由此，在多种情况下探讨AKT在辐射耐药机制中的意义。通过体外研究和临床研究，AKT是细胞内辐射耐药的重要分子机制之一。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy

DOI：
10.1016/j.radonc.2005.11.005
发表时间：
2006-01-01
期刊：
RADIOTHERAPY AND ONCOLOGY
影响因子：
5.7
作者：
Ejima, Y;Sasaki, R;Sugimura, K
通讯作者：
Sugimura, K

High Mutagen Sensitivity in Peripheral Blood Lymphocytes Predicts Poor Overall and Disease-Specific Survival in Patients with Stage III Non–Small Cell Lung Cancer Treated with Radiotherapy and Chemotherapy

外周血淋巴细胞的高诱变剂敏感性预示接受放疗和化疗的 III 期非小细胞肺癌患者总体生存率和疾病特异性生存率较差

DOI：
10.1158/1078-0432.ccr-04-2176
发表时间：
2005
期刊：
Clinical Cancer Research
影响因子：
11.5
作者：
Joe Y. Chang;R. Komaki;R. Sasaki;Z. Liao;C. Stevens;Charles Lu;F. Fossella;P. Allen;J. Cox;M. Spitz;Xifeng Wu
通讯作者：
Xifeng Wu

Efficacy and feasibility of cisplatin-based concurrent chemoradiotherapy for nasopharyngeal carcinoma

顺铂同步放化疗治疗鼻咽癌的疗效和可行性