How to enlarge the radiofrequency ablation area in the lung: experimental study

如何扩大肺部射频消融面积：实验研究

• 批准号: 17591271
• 负责人: KANAZAWA Susumu
• 金额: $ 2.43万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591271/
• 关键词: cancer; radiofrequency; ablation

Radiofrequency (RF) ablation is a new clinical procedure which has been applied for the treatment of lung malignancies for recent years.To improve clinical results, it is very important to enlarge the RF ablation area in the lung. One possible way to enlarge the ablation area is an injection of saline in the lung to improve RF induction. The other way is an artificial obstruction of the pulmonary artery in the ablation area to reduce the blood flow which cools the ablation area. The purpose of our study was to confirm the usefulness of these two interventions by animal experiment.Domestic pigs and LeVeen RF electrode with 2cm in diameter and RF 2000 or 3000 Generator system (Radiotherapeutics) were used in this experiment. Living pig's lung was ablated by RF with and without 3m1 of saline injection under the same ablation algorism then the pig was scarified. Macro-and microscopic examinations showed that the volume of the ablated area with saline injection was almost twice as much as that without saline injection and more homogenous ablation was observed with saline injection.In the next experiment, pig's lung was ablated with and without pulmonary arterial embolization with degradable starch micro-spheres (DSM) which could temporarily occlude vessels. Macro-and microscopic examinations showed that the volume of the ablated area with embolization was almost twice as much as that without embolization and the lung tissue was not injured by embolization.This study revealed the safety and usefulness of saline injection and temporary occlusion of the pulmonary artery when we try to enlarge the ablation area in the lung by RF.

射频消融是近年来应用于治疗肺部恶性肿瘤的一种新的临床治疗方法，扩大肺部射频消融面积对于提高临床效果非常重要。扩大消融区域的一种可能方法是向肺部注射盐水以改善射频感应。另一种方法是人工阻塞消融区域的肺动脉，以减少血流量，从而冷却消融区域。我们研究的目的是通过动物实验来证实这两种干预措施的有效性。本实验使用家猪和直径为2cm的LeVeen射频电极以及RF 2000或3000发生器系统（放射治疗）。在相同的消融算法下，在注射或不注射3m1盐水的情况下，通过射频消融活猪的肺，然后将猪处死。宏观和显微镜检查显示，注射生理盐水的消融区域体积几乎是未注射生理盐水的两倍，并且注射生理盐水观察到更均匀的消融。在接下来的实验中，使用可暂时闭塞血管的可降解淀粉微球（DSM）在有或没有肺动脉栓塞的情况下对猪的肺进行消融。宏观和显微镜检查显示，栓塞消融区域的体积几乎是未栓塞消融区域的两倍，并且肺组织没有受到栓塞损伤。本研究揭示了当我们尝试通过射频扩大肺部消融区域时，注射生理盐水和暂时闭塞肺动脉的安全性和有效性。

项目成果

気管冷却下に施行した縦隔リンパ節転移に対するラジオ波焼灼療法

气管冷却下射频消融治疗纵隔淋巴结转移

• 发表时间: 2006
• 期刊: 岡山医学会雑誌 118
• 作者: 平木隆夫;安井光太郎;三村秀文;郷原英夫;向井 敬;長谷聡一郎;藤原寛康;田尻展久;猶本良夫;山辻知樹;白川靖博;浅海信也;中塚秀輝;花崎元彦;森田 潔;田中紀章;金澤 右
• 通讯作者: 金澤 右

末梢肺腺癌に対するラジオ波治療

周围型肺腺癌的射频治疗

• 发表时间: 2007
• 期刊: 肺癌のすべて 21
• 作者: Kataoka M;Kido A;Koyama T;Isoda H;Umeoka S;Tamai K;Nakamoto Y;Maetani Y;Morisawa N;Saga T;Togashi K.;菅 一能;金澤 右
• 通讯作者: 金澤 右

Susumu Kanazawa, Effects of Radiofrequency Ablation on Individual Renal Function : Assessment by Technetium-99m Mercaptoacetyltriglycine Renal Scintigraphy

Susumu Kanazawa，射频消融对个体肾功能的影响：通过 Technetium-99m 巯基乙酰三甘氨酸肾闪烁扫描进行评估

• 发表时间: 2006
• 期刊: Acta Med. Okayama 60(20)
• 作者: Takashi Mukai;Shuhei Sato;Toshihiro Iguchi;Hidefumi Mimura;Kotaro Yasui;Hideo Gobara;Takashi Saika;Yasutomo Nasu;Hiromi Kumon
• 通讯作者: Hiromi Kumon

Intractable pneumothorax due to bronchopleural fistula after radiofrequency ablation of lung tumors

• DOI: 10.1016/j.jvir.2006.10.011
• 发表时间: 2007-01-01
• 期刊: JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
• 影响因子: 2.9
• 作者: Sakurai, Jun;Hiraki, Takao;Kanazawa, Susumu
• 通讯作者: Kanazawa, Susumu

肺腫瘍のRFA

RFA 治疗肺部肿瘤

• 发表时间: 2006
• 期刊: 臨床放射線 51(11)
• 作者: 安井光太郎;金澤 右;郷原英夫;向井 敬;平木隆夫;長谷聡一郎;藤原寛康;戸上 泉;井上信浩;守都常晴;長谷川 明
• 通讯作者: 長谷川 明