Choice-predicting neurons in the prelimbic cortex during a modified Iowa-gambling-task for rats

在修改后的爱荷华州赌博任务中，大鼠前边缘皮质中的选择预测神经元

• 批准号: 465200874
• 负责人: Professor Dr. Thomas Klausberger
• 金额: --
• 依托单位: Department of Cognitive Neurobiology
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/465200874?language=en
• 关键词: Choice; predicting; neurons; prelimbic; cortex

Success often depends on inspired choices between risk-taking for exciting achievements or perseverance with safe, incremental advancements. In this project we aim to discover neuronal firing patterns triggering such inspired decisions based on internal valuations of probabilistic evidence. We will train rats to perform a modified-Iowa-gambling-task, successfully adjusting choices between certain-small, or possible-big rewards with changing long-term advantages. Recently (Passecker et al., 2019), we have discovered a subset of specialized neurons in the prelimbic subdivision (PL) of medial PFC, whose firing predict the subsequent decision of the animal, even for unlikely choices. During this project, we will perform juxtacellular recording and labelling of these neurons to determine their cellular identity and axonal projections, we will manipulate neuronal activity during the gambling task and we will develop computational models to explain the network dynamics underlying choices during gambling and dynamically adjusting decisions based on internal valuations.

成功往往取决于在冒险取得令人兴奋的成就或坚持安全，渐进的进步之间的灵感选择。在这个项目中，我们的目标是发现神经元放电模式触发这种灵感的决定的基础上的内部估值的概率证据。我们将训练大鼠执行改良的爱荷华赌博任务，成功地调整选择之间的某些小，或可能的大奖励与改变长期优势。最近（Passecker et al.，2019年），我们已经发现了一个专门的神经元的子集，在内侧PFC的前边缘细分（PL），其发射预测动物的后续决策，即使是不太可能的选择。在这个项目中，我们将对这些神经元进行细胞内记录和标记，以确定它们的细胞身份和轴突投射，我们将在赌博任务中操纵神经元活动，我们将开发计算模型来解释赌博过程中选择的网络动力学，并根据内部估值动态调整决策。