Developmental Contributions to the Functional Maturation of the Vestibulo-Ocular Reflex
前庭眼反射功能成熟的发育贡献
基本信息
- 批准号:10679875
- 负责人:
- 金额:$ 4.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAddressAnatomyAnimal BehaviorAnimalsAutomobile DrivingBehaviorBiological AssayBirthBirth OrderBrainBrain StemChildhoodDataDate of birthDevelopmentDevelopmental ProcessDiseaseEarEventEye MovementsFunctional disorderGeneticGoalsHeadHealthHumanImageImpaired healthKnowledgeLesionLinkLocationMeasuresMissionModelingMotor NeuronsMovementNeurodevelopmental DisorderNeuronsNeurosciencesNoseOpticsPlayPopulationPopulation HeterogeneityPropertyProtocols documentationPublic HealthResearchRoleSensoryShapesSystemTechnologyTestingTimeUnited States National Institutes of HealthWorkZebrafishassay developmentassociated symptomdevelopmental diseasedisabling symptomexperimental studygain of functiongazeimprovedloss of functionneuralneural circuitneurodevelopmentneuronal circuitryoptogeneticsphenomenological modelspredicting responseresponseserial imagingvestibulo-ocular reflex
项目摘要
PROJECT SUMMARY
During development, animal behaviors improve as neural circuits refine. Prior work suggests that early
developmental events, such as birth timing, define the role a neuron will play in a circuit. However, the
complexity of most developing circuits and the behaviors they subserve limit our understanding of the role of
early events in circuit maturation. My proposed experiments address this gap by asking if early development
shapes circuit maturation. Defining the relationship between development and function is key to understand
the how the brain and behavior mature in healthy and diseased states.
The larval zebrafish is a particularly tractable model for circuit development due to its genetic accessibility,
transparency, and rapid external development. Specifically, the neuronal populations driving gaze stabilization
following body tilts in the larval zebrafish are well-conserved and orders of magnitude smaller. Our lab
leverages these advantages to link developmental phenomenology with circuit maturation and behavior. We
have established genetic and optical means to longitudinally measure and manipulate neural activity across
development. Importantly, prior work from our lab has revealed that the birthdate of vestibular neurons
influences anatomical location within the brainstem and preferred direction of body tilt.
The goal of this proposal is to determine if birthdate similarly predicts how sensory responses
mature, and if birthdate predicts a neuron’s contribution to behavior. In Aim 1, I will determine if a central
vestibular neuron’s birthdate predicts its sensitivity to body tilts of different magnitudes, and/or how this
encoding matures. In Aim 2, I will examine how developmentally and functionally diverse populations of
vestibular neurons contribute to behavior using loss- and gain-of-function approaches. My data will define the
role of early development in circuit function. Completion of these experiments will speak to the general
mechanisms by which circuit function is influenced by – or indifferent to – early development.
项目摘要
在发育过程中,动物的行为随着神经回路的完善而改善。先前的研究表明,
发育事件,如出生时间,决定了神经元在回路中的作用。但
大多数发育中的电路的复杂性和它们所支持的行为限制了我们对
电路成熟的早期事件。我提出的实验通过询问早期发育是否
形成电路成熟。定义开发和功能之间的关系是理解
大脑和行为在健康和疾病状态下是如何成熟的。
由于其遗传可及性,斑马鱼幼体是电路发育的特别易处理的模型,
透明度和快速的外部发展。具体来说,驱动凝视稳定的神经元群体
随后的身体倾斜在斑马鱼幼虫中是很好的保守和数量级较小。我们实验室
利用这些优势将发育现象学与回路成熟和行为联系起来。我们
已经建立了遗传和光学手段来纵向测量和操纵神经活动,
发展重要的是,我们实验室之前的工作已经揭示了前庭神经元的出生日期
影响脑干内的解剖位置和身体倾斜的首选方向。
这项提议的目的是确定出生日期是否同样预测了感官反应
成熟,如果出生日期预测神经元对行为的贡献。在目标1中,我将确定
前庭神经元的出生日期预测了它对不同幅度的身体倾斜的敏感性,和/或这是如何发生的。
编码成熟。在目标2中,我将研究发育和功能多样性的人群是如何发展的。
前庭神经元使用功能丧失和获得方法对行为作出贡献。我的数据将定义
早期发育在电路功能中的作用。这些实验的完成将对将军
回路功能受早期发育影响或不受影响的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Paige Leary其他文献
Paige Leary的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 4.44万 - 项目类别:
Research Grant