The role of chromatin in the establishment of inter-chromosomal DNA-DNA interactions (A33*)

染色质在建立染色体间 DNA-DNA 相互作用中的作用 (A33*)

• 批准号: 467294763
• 金额: --
• 依托单位: Experimentelle Parasitologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/467294763?language=en
• 关键词: role; chromatin; establishment; inter; chromosomal

Inter-chromosomal interactions are essential for gene regulation in numerous biological systems including the mutually exclusive antigen expression in African Trypanosomes. Yet, very little is known about the mechanisms leading to the establishment and maintenance of such interactions. The goal of the work proposed here is to combine different live-cell imaging approaches and proteomics-based chromatin analyses to determine the molecular factors responsible for the establishment and maintenance of distinct inter-chromosomal DNA-DNA interactions in Trypanosoma brucei.

染色体间的相互作用对于许多生物系统中的基因调控是必不可少的，包括非洲锥虫中相互排斥的抗原表达。然而，很少有人知道的机制，导致建立和维持这种相互作用。本文提出的工作目标是结合联合收割机不同的活细胞成像方法和基于蛋白质组学的染色质分析，以确定负责建立和维持布氏锥虫不同染色体间DNA-DNA相互作用的分子因素。