Memory acquisition and consolidation in layer 1 of the neocortex

新皮质第一层的记忆获取和巩固

• 批准号: 467613712
• 负责人: Professor Matthew Larkum
• 金额: --
• 依托单位: Arbeitsgruppe Neuronale Plastizität
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/467613712?language=en
• 关键词: Memory; acquisition; consolidation; layer; neocortex

Converging evidence suggests that neocortical layer 1 is important for learning and memory. We have preliminary evidence that the final stage of the medial-temporal loop, the perirhinal cortex connection to neocortex, is vital for learning in a simple microstimulation task. The axons of this projection terminate in layer 1 of the neocortex and affect dendritic calcium in layer 5 pyramidal neurons. Moreover, the perirhinal cortex is known to be important in the novel object recognition behavioural paradigm. Here, we propose to adapt this behavioural task to our recently developed floating-platform approach (“Air-Track”) to allow this traditionally freely-moving task to be carried out under head-fixation opening up the possibility of using approaches such as 2-photon imaging to investigate the underlying mechanisms of layer-1 dependent plasticity during behaviour.

综合证据表明，新皮质第一层对于学习和记忆非常重要。我们有初步证据表明，内侧颞环的最后阶段，即鼻周皮层与新皮层的连接，对于简单微刺激任务的学习至关重要。该投射的轴突终止于新皮质的第 1 层，并影响第 5 层锥体神经元的树突状钙。此外，众所周知，鼻周皮层在新的物体识别行为范式中很重要。在这里，我们建议将此行为任务适应我们最近开发的浮动平台方法（“Air-Track”），以允许这种传统的自由移动任务在头部固定下进行，从而开启了使用 2 光子成像等方法来研究行为过程中第 1 层依赖可塑性的潜在机制的可能性。