Activity-Dependent Mechanisms of Memory Consolidation

记忆巩固的活动依赖性机制

• 批准号: 10534735
• 负责人: MARK S GOLDMAN
• 金额: $ 58.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534735
• 关键词: Amygdaloid structure; Area; Automobile Driving; Behavior; Behavioral; Brain; Brain region; Cell Nucleus; Cerebellum; Cognition; Computer Models; Data; Dissection; Episodic memory; Eye Movements; Foundations; Goals; Hippocampus; Individual; Learning; Measures; Mediating; Memory; Modeling; Motor Skills; Movement; Nature; Neurons; Output; Process; Research; Sensory; Shapes; Short-Term Memory; Site; Societies; Synapses; System; Testing; Time; Training; Vision; Work; candidate identification; conditioned fear; density; experience; experimental study; improved; in vivo; insight; long term memory; medial vestibular nucleus; memory acquisition; memory consolidation; motor learning; neural; neural circuit; neural patterning; neurotransmission; oculomotor; optogenetics; predictive modeling; transmission process; visual information

PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning adjusts the neural circuitry controlling eye movements, to maintain the accuracy of eye movements over short and long time scales. The specific focus of the research is to understand how oculomotor learning, i.e., improvement of the accuracy of eye movements through experience, is transferred from short-term to long-term storage. This consolidation process occurs, not only for motor skills like eye movements, but is a general feature of learning and memory systems. Some memories, including oculomotor memories, are transformed during the time after the initial acquisition of the memory, in a way that renders older, consolidated memories independent of brain areas that are critical for newer memories. This process, known as systems consolidation, is thought to depend on activity of neurons in the brain area initially critical for the memory, and the hypothesis is that this activity induces changes in the brain area(s) supporting long-term storage of the memory. The proposed research characterizes the nature of the neural signals transmitted between brain areas supporting memory at different times after their acquisition, and the rules that operate on those neural signals to implement stable transfer of a memory from one brain area to another.

项目总结