Asymmetric Synthesis of Chiral Molecules

不对称合成技术的发展迅速而广泛，在许多情况下，它是一种比酶反应更普遍、更有效的合成光性手性化合物的新方法。“手性分子的不对称合成”项目由62名有机化学家组成，分为不对称空间、典型金属催化剂、过渡金属催化剂和不对称全合成四个课题组，从1993年开始，历时三年，旨在利用典型元素和过渡元素的特性，创造各种新的不对称反应；但也应用许多对映和非对映选择反应来合成复杂的多手性化合物，包括有用的天然产物。1993-1995年期间，开发了许多与diols有关的新的不对称反应- alder、ene、aldol、nitroaldol、Michael、烷基化、质子化和硅氢化反应，并完成了许多复杂天然产物的合成。本报告是所有项目成员取得的典型成果的汇编，将有助于促进项目成员和许多其他有机化学家的新研究。

Asymmetric synthesis has developed rapidly and extensively, and is now growing into a new way of producing optically active chiral compounds that is more general and efficient than enzymatic reactions in many cases. The aim of this project "asymmetric synthesis of chiral molecules", which was executed by 62 organic chemists dividing into four research groups of asymmetric space, typical metal catalyst, transition metal catalyst and asymmetric total synthesis for three years beginning in 1993, was not only create various new asymmetric reactions by taking advantage of characteristics of typical and transition elements, but also to apply many enantio- and diastereoselective reactions to the synthesis of complex multi-chiral compounds including useful natural products.During 1993-1995, many new asymmetric reactions related to Diels-Alder, ene, aldol, nitroaldol, Michael, alkylation, protonationa and hydrosilylation reactions were developed, and many syntheses of complex natural products were also completed. This report is a compilation of typical results achieved by all the project members, and will assist the promotion of new research of not only the project members but many other organic chemists.