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Humoral mechanisms controlling feed intake in large bodied meat producing goats

控制大型产肉山羊采食量的体液机制

基本信息

批准号：
14560237
负责人：
SUNAGAWA Katsunori
金额：
$ 1.98万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14560237/
关键词：
Large bodied meat producing goats Dry forage Feed intake control Humoral controlling mechanisms Neuronal peptides

项目摘要

Okinawan farmers have, through a system of heterosis, bred a large bodied goats for its meat. This hybrid-breed of goats grows rapidly and body weight can exceed 80 kg in its first year. Traditionally, goats have fed on the leaves of trees. The hybrid-breed of large bodied goats however, are similar to cows in that they will feed on goats, and can be raised on dry roughage. This makes large scale farming of the goat possible. However, when the animals are fed on dry roughage, feeding behavior is rapidly suppressed during the initial stages of feeding. This research, entitled "Humoral mechanisms controlling feed intake in large bodied meat producing goats" was carried out between 2002-2004. The main purpose of this study was to clarify the mechanisms that suppress dry roughage intake in large-bodied meat producing goats. It was hypothesized that a disturbance of the blood properties brought about by the marked increase in saliva secretion during the initial stages of dry forage intake, … More is possibly linked to the suppression of feed intake. When parotid saliva collected from parotid fistulated goats was infused into the rumen prior to the commencement of dry forage feeding, the degree of feed intake suppression was reduced. Next, research was conducted to establish which components of saliva, when lost, cause feed intake suppression. To establish this, both the loss of mixed saliva(hypo-osmotic) and the lost of parotid saliva(iso-osmotic) were separately investigated. In both cases, it was established that decreases in plasma volumes(hypovolemia) caused by fluid lost in the form of saliva, caused feed intake suppression. It is further hypothesized that there are periferal factors at work that produce thirst sensations in the brain and suppress feed intake. Work was conducted to examine whether or not feed intake suppression was reduced when the production and release of neural transmitters, related to thirst sensations produced in the brain when feeding on dry forage, was suppressed by an intraventricular infusion of somatostatin. The results suggested that peptides in the brain contribute to the suppression of feed intake during the initial stages of dry forage feeding. It is hoped that the neural transmitters will be identified in later research. The present experiment resulted in the clarification of one part of the feed intake controlling mechanisms at work in large bodied meat producing goats during the initial stages of dry forage feeding. Appearing in this report are the published papers, and drafts currently under consideration by journal reviewers. This research was made possible by a Grant-in-aid for Exploratory Research from the Ministry of Education, Science, Sports and Culture in Japan. While it is possible to farm large bodied meat producing goats in large numbers by feeding them dry forage in the same manner as cows and sheep, it is thought that more research is needed on the mechanisms that suppress feed intake, and methods with which to overcome this feed intake suppression. In conclusion, any comments or opinions regarding our research the "Humoral mechanisms controlling feed intake in large bodied meat producing goats" would be most welcome. We would like to express our thanks to the Ministry of Education, Science, Sports and Culture for their Grant-in-aid that made this 3 year research possible. Less

冲绳的农民通过杂种优势系统培育出了体型较大的山羊，以获取其肉。这种杂交山羊生长迅速，第一年体重可超过80公斤。传统上，山羊以树叶为食。然而，大体型山羊的杂交品种与奶牛相似，它们以山羊为食，可以用干粗饲料饲养。这使得山羊的大规模养殖成为可能。然而，当动物饲喂干粗饲料时，摄食行为在摄食的初始阶段迅速受到抑制。这项名为“控制大型产肉山羊采食量的体液机制”的研究于2002-2004年间进行。本研究的主要目的是阐明抑制大型产肉山羊干粗饲料摄入量的机制。据推测，在采干草料的初期，唾液分泌的显著增加引起了血液特性的紊乱……更多的可能与采食量的抑制有关。在干草料饲喂前将腮腺瘘管山羊的腮腺唾液注入瘤胃，可降低其采食量抑制程度。接下来，进行了研究，以确定唾液的哪些成分在失去时导致采食量抑制。为了证实这一点，我们分别研究了混合唾液的损失（低渗透）和腮腺唾液的损失（等渗透）。在这两种情况下，已经确定，由于唾液形式的液体损失导致血浆体积减少（低血容量），导致采食量减少。进一步的假设是，在大脑中产生口渴感觉并抑制采食量的周围因素在起作用。研究人员通过脑室内注入生长抑素来抑制神经递质的产生和释放（与大脑在进食干燥草料时产生的口渴感觉有关），是否会减少采食量抑制。结果表明，在干草料饲喂初期，脑内肽抑制了采食量。希望在以后的研究中能够识别出这些神经递质。本试验结果澄清了大体产肉山羊在干草料饲喂初期采食量控制机制的一部分。本报告中出现的是已发表的论文，以及期刊审稿人目前正在考虑的草稿。这项研究是由日本教育、科学、体育和文化部提供的探索性研究补助金所支持的。虽然可以用与牛羊相同的方式喂养干草料来大量养殖大型肉羊，但人们认为需要对抑制采食量的机制和克服这种采食量抑制的方法进行更多的研究。综上所述，欢迎各位对我们的研究“大体型产肉山羊采食量的体液机制”提出意见和建议。我们要感谢教育、科学、体育和文化部的资助，使这项为期3年的研究成为可能。少

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Controlling Factors of Feed Intake and Salivary Secretion in Goats Fed on Dry Forage

干草饲喂山羊采食量和唾液分泌的控制因素

DOI：
发表时间：
2005
期刊：
Asian-Australasian Journal of Animal Science 18
影响因子：
0
作者：
K.Nakade;M.Muguruma;Y.Inoue;S.Kawahara;K.Yamuchi;T.Nakayama;M.Maruyama;T.Okayama;M.Numata;Sunagawa K.et al.
通讯作者：
Sunagawa K.et al.

Effect of Parotid Saliva Secretion on Dry Forage Intake in Goats.

腮腺唾液分泌对山羊干饲料采食量的影响。

DOI：
发表时间：
2003
期刊：
Asian-Australasian Journal of Animal Sciences 16・8
影响因子：
0
作者：
島田聡子;横山千端子;高篠景子;神勝紀;唐澤豊;Sunagawa K.et al.
通讯作者：
Sunagawa K.et al.

Controlling Factors of Feed Intake and Salivary Secretion in Goats Fed on Dry Forage.

干饲料喂养山羊采食量和唾液分泌的控制因素。

DOI：
发表时间：
2005
期刊：
Asian-Australasian Journal of Animal Sciences 18(in press)
影响因子：
0
作者：
H.Katayama;M.Tomatsu;S.Kawahara;K.Yamauchi;H.Fuchu;Y.Kodama;Y.Kawamura;M.Muguruma;Sunagawa K.et al.
通讯作者：
Sunagawa K.et al.

Effects of inravenous infusion of artificial saliva and mannitol solusion on feeding induced hypovolemia and dry forage intake in goats.

静脉输注人工唾液和甘露醇溶液对山羊饲喂引起的低血容量和干草采食量的影响。