Molecular epidemiologic study on lung adenocarcinoma : interaction between cigarette smoking and metabolic polymorphisms

肺腺癌的分子流行病学研究：吸烟与代谢多态性之间的相互作用

• 批准号: 14570300
• 负责人: KIYOHARA Chikako
• 金额: $ 2.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570300/
• 关键词: lung adenocarcinoma; cytochrome P4502A6; cytochrome P4502A13; molecular enidemiology; tobacco stecific N-nitrosamine; 薬物代謝酵素; 喫煙; 交互作用; チトクローム P4502A6 (CYP2A6); 肺腺がん; CYP2A6遺伝子多型

We examined the relationship between the CYP2A6 and CYP2A13 in Japanese in a case-control study. In this study. we genotyped 179 patients with lung cancer and 96 controls for these two polymorphisms to examine the hypothesis that the variant genotype maybe associated with the risk of lung cancer, particularly adenocarcinoma. No association was observed between the risk of lung cancer and CYP2A6 genotype. According to histological type, compared with one or more copies of the variant allele, the CYP2A13 CC genotype was the most strongly associated with adenocarcinoma (OR=1.67), but this result was compatible with chance [95% confidence interval (CI)=0.37-7.50]. A gene-environment interaction among patients with adenocarcinoma was suggested, with combined the CYP2A13 CC genotype and smoking conferring significantly higher risk (OR=2.80, 95% CI =1.30-6.13), compared to possession at least one copy of the CYP2A13 T allele and non-smoking. These results indicate that CYP2A13 gene and not CYP2A6 may play an important role in the development of lung adenocarcinoma among smokers. Additional studies are warranted to corroborate the smoking-CYP2A13 polymorphism interaction among patients with adenocarcinoma suggested in the present study.

我们在一项病例对照研究中研究了日本人CYP 2A 6和CYP 2A 13之间的关系。本研究我们对179名肺癌患者和96名对照进行了这两种多态性的基因分型，以检验变异基因型可能与肺癌，特别是腺癌的风险相关的假设。未观察到肺癌风险与CYP 2A 6基因型之间的关联。根据组织学类型，与变异等位基因的一个或多个拷贝相比，CYP 2A 13 CC基因型与腺癌的相关性最强（OR=1.67），但这一结果与偶然性[95%置信区间（CI）=0.37-7.50]相一致。提示腺癌患者中存在基因-环境相互作用，与至少拥有一个CYP 2A 13 T等位基因拷贝和不吸烟者相比，CYP 2A 13 CC基因型和吸烟者的风险显著更高（OR=2.80，95%CI =1.30-6.13）。提示CYP 2A 13基因可能在吸烟者肺腺癌的发生发展中起重要作用，而CYP 2A 6基因可能不起作用。需要进一步的研究来证实本研究中提出的腺癌患者中吸烟-CYP 2A 13多态性相互作用。

项目成果

Yoshimasu K, Kiyohara C.: "Genetic influences on smoking behavior and nicotine dependence : a review."J Epidemiol. 13(4). 183-192 (2003)

Yoshimasu K、Kiyohara C.：“遗传对吸烟行为和尼古丁依赖的影响：综述。”J Epidemiol。

Yoshimasu K, Kiyohara C: "Genetic influences on smoking behavior and nicotine dependence : a review."Journal of Epidemiology. 13. 183-192 (2003)

Yoshimasu K、Kiyohara C：“遗传对吸烟行为和尼古丁依赖的影响：综述。”流行病学杂志。