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Study on glycol ethers-caused damages in the reproductive and haematopoietic systems and the underlying mechanisms in human

乙二醇醚对人体生殖和造血系统的损害及其机制研究

基本信息

批准号：
14570317
负责人：
WANG Rui-sheng
金额：
$ 2.18万
依托单位：
National Institute of Occupational Safety and Health, Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Ethylene glycol monoethyl ether(EGEE) is one of a family of glycol ethers widely used as an organic solvent for resins, paints and dyes, and as a thinner in industry. It is miscible with both water and other organic solvents, and can be easily absorbed through the skin as well as via inhalation. Exposure to the solvent ethylene glycol monoethyl ether(EGEE) is known to cause haematological and reproductive disorders. The main metabolic pathway of the solvent is oxidation to ethoxyacetic aldehyde by alcohol dehydrogenase, followed by oxidation of the aldehyde to ethoxyacetic acid by aldehyde dehydrogenase(ALDH), which is subsequently excreted in urine. The biotransformation of EGEE plays an important role in the expression of its toxicity. ALDH2 is the major enzyme in the metabolism of many short chain aliphatic aldehydes including ethoxyacetic aldehyde. On the other hand, approximately 30% of Asians possess the ALDH2^*2 allele encoding the inactive enzyme, in relation to the wild type A … More LDH2^*1 allele. The allele ALDH2^*2 is from the single nucleotide polymorphisms at nucleotide 1510 (G/A) of the gene, resulting in a substitution of Glu to Lys at the amino acid position 487. The aim of our study was to investigate whether ALDH2 polymorphisms influenced the toxic effects of EGEE among exposed workers. It was shown that sperm count, progressive vitality and normal morphology percentage were all decreased in males exposed to high concentrations of EGEE. Blood concentrations of the sex-related hormones such as testosterone, LH and FSH were not affected by the organic solvent at current exposure levels. RBC count and haemoglobin content were lower in the exposed group when compared to non-exposed controls. Genetic polymorphisms of ALDH2 affected the toxicity of EGEE in both spermatogenesis and hematopoiesis. Overall, our study suggests that ALDH2^*2 may be a protective factor against damage caused by EGEE, and this result is very useful in the practice of occupational health. Less

乙二醇单乙醚(EGEE)是乙二醇醚家族中的一种，广泛用作树脂、涂料和染料的有机溶剂，并在工业上用作稀释剂。它可以与水和其他有机溶剂混溶，可以很容易地通过皮肤和吸入吸收。已知接触溶剂乙二醇单乙醚(EGEE)会导致血液和生殖障碍。该溶剂的主要代谢途径是乙醇脱氢酶将乙氧基乙醛氧化为乙氧基乙醛，然后由乙醛脱氢酶(ALDH)将乙氧基乙酸氧化为乙氧基乙酸乙酯，最终通过尿液排出。EGEE的生物转化在其毒性表达中起着重要作用。ALDH2是包括乙氧基乙醛在内的许多短链脂肪醛代谢的主要酶。另一方面，大约30%的亚洲人拥有编码失活酶的ALDH2^*2等位基因，这与野生型A…有关更多的LDH2^*1等位基因。等位基因ALDH2^*2来自该基因第1510位核苷酸(G/A)的单核苷酸多态，导致第487位氨基酸的Glu替换为Lys。本研究旨在探讨ALDH2基因多态性是否影响接触工人中EGEE的毒性效应。结果表明，接触高浓度EGEE的男性精子数、精子进行性活力和正常形态百分率均下降。在目前的暴露水平下，血液中与性相关的激素如睾酮、黄体生成素和卵泡刺激素的浓度不受有机溶剂的影响。与非接触组相比，接触组的红细胞计数和血红蛋白含量较低。ALDH2基因多态性影响EGEE的生精和造血毒性。总之，我们的研究表明，ALDH2^*2可能是一种保护因子，对EGEE造成的损害具有保护作用，这一结果在职业健康实践中非常有用。较少

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Imbalance of testosterone level in male offspring rats perinatally exposed to bisphenol A.

围产期暴露于双酚 A 的雄性子代大鼠睾酮水平失衡。

DOI：
发表时间：
2003
期刊：
Industrial Health 41
影响因子：
0
作者：
Sumiko Watanabe;Rui-Sheng Wang;Muneyuki Miyagawa;Kenichi Kobayashi;Megumi Suda;Soichiro Sekiguchi;Takeshi Honma
通讯作者：
Takeshi Honma

Health effects of exposure to ethylene glycol monoethyl ether in female workers

女工接触乙二醇单乙醚对健康的影响