The effects of estrogen like agents on cardio-protection via induction of stress proteins

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Sex difference is one of the major factors that modulate pathogenesis of heart diseases. Especially in ischemic heart diseases, anti-atherogenic actions of estrogen were examined extensively. However, the action of estrogen on cardiac myocytes per sue was not elucidated yet. Therefore, we examined the effect of 17β-estradiol on cultured cardiac myocytes. We utilized P19CL6 cell line as cardiac progenitor system and differentiated them into cardiac phenotype with DMSO. 17β-estradiol induced manganese superoxide dismutase in differentiated P19CL6 cells and increased tolerance of the cells to hydrogen peroxide. We also examined whether 176-estradiol promote differentiation of P19CL6 cells into cardiac phenotype. P19CL6 cells treated with DMSO started spontaneous beating earlier in the presence of 176-estradiol compared to control cells without estradiol. These results indicate that 17β-estradiol causes cardioprotective action directly on cardiac myocytes through the increase in the tolerance of myocytes to oxidative stress and the promotion of myocyte regeneration from progenitor cells.