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Assessment of metabolic disorders of fatty acid and glucose in various myocardial pathologies with Rutland analysis of I-123 BMIPP dynamic SPECT data and F-18 FDG PET studies.

通过 I-123 BMIPP 动态 SPECT 数据和 F-18 FDG PET 研究的拉特兰分析来评估各种心肌病理中脂肪酸和葡萄糖的代谢紊乱。

基本信息

批准号：
14570850
负责人：
TAKEDA Kan
金额：
$ 2.11万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Fatty acid metabolic disorder was assessed in ischemic myocardium and myocardial damage induced by anti-cancer drug using I-123 beta-metyl-idophenyl-pentadecanoic acid(BMIPP) dynamic SPECT data with analysis by the Rutland method. Dynamic SPECT data were obtained after bolus injection of I-123 BMIPP using 3-head SPECT system. On analysis of the obtained data by the Rutland method, uptake constant of BMIPP (K value) and the time when the excretion of BMIPP from the myocardium began (Tex) were calculated. Informed consents were obtained in all patients.1)In ischemic myocardium, K values were significantly decreased and Tex was strikingly shortened as compared with the normal myocardium. In Doxorubicin-induced myocardial damage, by contrast, K values were considerably decreased but Tex was significantly prolonged in comparison with the normal myocardium. These results suggested that the main cause of fatty acid metabolism was increased back diffusion in ischemic myocardium, but decreased metabolic rate of fatty acid in Doxorubicin-induced myocardial damage.2)Same assessment was performed in another anti-cancer drug, Taxane. Myocardial BMIPP SPECT images were impaired and K values were significantly decreased after administration of Taxane. These fatty acid metabolic disorders were detected before the appearance of functional impairment of left ventricle. Thus, these methods are promising in early detection of myocardial damage induced by anti-cancer drugs.

采用I-123 β -甲基-异苯五酸（BMIPP）动态SPECT数据，采用Rutland法分析缺血心肌的脂肪酸代谢紊乱和抗癌药物引起的心肌损伤。采用3头显像系统对I-123 BMIPP进行灌注后，获得动态显像数据。通过Rutland法分析得到的数据，计算BMIPP摄取常数（K值）和BMIPP从心肌开始排泄的时间（Tex）。所有患者均获得知情同意。1)缺血心肌与正常心肌相比，K值明显降低，Tex明显缩短。在阿霉素诱导的心肌损伤中，与正常心肌相比，K值明显降低，但Tex明显延长。提示脂肪酸代谢的主要原因是缺血心肌后向扩散增加，而阿霉素诱导心肌损伤时脂肪酸代谢率降低。2)另一种抗癌药物紫杉烷也进行了相同的评估。紫杉烷给药后心肌BMIPP SPECT图像受损，K值明显降低。这些脂肪酸代谢紊乱在左心室功能损害出现之前就被检测到。因此，这些方法在抗癌药致心肌损伤的早期检测中具有广阔的应用前景。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Assessment of fatty acid metabolism in taxane-induced myocardial damage with iodine-123 BMIPP SPECT : comparative study with myocardial perfusion, left ventricular function, histopathological findings

用碘 123 BMIPP SPECT 评估紫杉烷诱导的心肌损伤中的脂肪酸代谢：与心肌灌注、左心室功能、组织病理学结果的比较研究

DOI：
发表时间：
2003
期刊：
Ann Nucl Med 17
影响因子：
0
作者：
kimimasa Saito;Kan Takeda;Kyoko Imanaka-Yoshida;ほか3人
通讯作者：
ほか3人

Kimimasa Saito, Kan Takeda他: "Assessment of fatty acid metabolism in taxan-induced myocardial damage with I-123 BMIPP SPECT"Annals of Nuclear Medicine. 17・6. 481-488 (2003)

Kimimasa Saito、Kan Takeda 等：“利用 I-123 BMIPP SPECT 评估紫杉烷诱导的心肌损伤中的脂肪酸代谢”《核医学年鉴》17・6 (2003)。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

Assessment of atty acid metabolism in taxan-induced myocardial damage with iodine-123 BMIPP SPECT : comparative study with myocardial per fusion, left ventricular function, and histopathological findings.

用碘 123 BMIPP SPECT 评估紫杉烷诱导的心肌损伤中的脂肪酸代谢：与心肌灌注融合、左心室功能和组织病理学结果的比较研究。

DOI：
发表时间：
2003
期刊：
Ann Nucl Med 17
影响因子：
0
作者：
Kimimasa Saito;Kan Takeda;Kyoko Imanaka-Yoshida;Hiroshi Imai;Takao Sekine;Yuko Kamikura
通讯作者：
Yuko Kamikura