Assessment of metabolic disorders of fatty acid and glucose in various myocardial pathologies with Rutland analysis of I-123 BMIPP dynamic SPECT data and F-18 FDG PET studies.

点击翻译按钮获取中文摘要

Fatty acid metabolic disorder was assessed in ischemic myocardium and myocardial damage induced by anti-cancer drug using I-123 beta-metyl-idophenyl-pentadecanoic acid(BMIPP) dynamic SPECT data with analysis by the Rutland method. Dynamic SPECT data were obtained after bolus injection of I-123 BMIPP using 3-head SPECT system. On analysis of the obtained data by the Rutland method, uptake constant of BMIPP (K value) and the time when the excretion of BMIPP from the myocardium began (Tex) were calculated. Informed consents were obtained in all patients.1)In ischemic myocardium, K values were significantly decreased and Tex was strikingly shortened as compared with the normal myocardium. In Doxorubicin-induced myocardial damage, by contrast, K values were considerably decreased but Tex was significantly prolonged in comparison with the normal myocardium. These results suggested that the main cause of fatty acid metabolism was increased back diffusion in ischemic myocardium, but decreased metabolic rate of fatty acid in Doxorubicin-induced myocardial damage.2)Same assessment was performed in another anti-cancer drug, Taxane. Myocardial BMIPP SPECT images were impaired and K values were significantly decreased after administration of Taxane. These fatty acid metabolic disorders were detected before the appearance of functional impairment of left ventricle. Thus, these methods are promising in early detection of myocardial damage induced by anti-cancer drugs.