Slowing Atherothrombosis Progression through Indoor Air Filtration: A Crossover Trial in Hispanic and non-Hispanic Adults with Ischemic Heart Disease History
通过室内空气过滤减缓动脉粥样硬化血栓形成的进展:对有缺血性心脏病史的西班牙裔和非西班牙裔成年人进行的交叉试验
基本信息
- 批准号:10688095
- 负责人:
- 金额:$ 65.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAdultAdverse effectsAgeAgingAirAir PollutionAreaAtherosclerosisBiological MarkersBlood GlucoseBlood PressureBlood coagulationC-reactive proteinCalendarCalibrationCaliforniaCardiometabolic DiseaseCardiovascular DiseasesCause of DeathCensusesChinaClinicalComputerized Medical RecordCross-Over StudiesCross-Over TrialsCrossover DesignDataDevicesDiabetes MellitusDouble-Blind MethodElderlyEnrollmentEnvironmental Risk FactorEthnic OriginEventExposure toFemaleFiltrationFutureGoalsHealthHeart failureHispanicHispanic PopulationsHome visitationIn VitroIncidenceIndividualInflammatoryInterleukin-6InternationalInterventionIntervention TrialLifeLife StyleLinkLos AngelesMeasuresMethodsMinority GroupsMonitorMorbidity - disease rateMulticenter TrialsMyocardial InfarctionMyocardial IschemiaNot Hispanic or LatinoOlder PopulationOutcomeP-SelectinParticipantParticulatePatientsPersonsPhysiologic pulsePlasmaPollutionPopulation HeterogeneityPopulations at RiskPredispositionProcessProteomicsQuestionnairesRandomizedRecording of previous eventsResearch DesignResearch PersonnelRiskRisk FactorsSamplingSpecific qualifier valueStatistical Data InterpretationStrokeSubgroupSudden DeathTeenagersThrombosisTimeUnited StatesUnited States National Institutes of HealthUniversitiesUniversity resourcesVariantVulnerable PopulationsWildfireWomanair cleanerair filtrationair monitoringarterial stiffnessatherothrombosisburden of illnesscardiovascular disorder riskcardiovascular risk factorcostdesignefficacy evaluationefficacy testingepidemiology studyethnic diversityexperiencefeasibility trialfine particleshigh efficiency particulate air filterimprovedin vivoindexingindoor airindoor particulate matterinterestmalemenmeteorological datamortalitynon-smokernovelpollutantportabilitypreventprimary outcomeresidenceresponsesecondary outcomesexsystemic inflammatory responsetreatment armtrial comparingvon Willebrand Factor
项目摘要
ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in the US. There has been an increasing
recognition of the important contribution of fine particulate pollution (PM2.5) to CVD morbidity and mortality.
Mounting evidence suggests that the use of indoor air filtration to reduce PM2.5 exposure from days to weeks
leads to improvement in acute atherothrombosis biomarkers. However, no trials have assessed whether these
short-term effects are sustained or further improved with prolonged filtration. The proposed study is the longest
intervention trial investigating the effect of using low-cost air purifiers in residences on ameliorating
atherothrombosis progressions in vulnerable individuals. The study will examine atherothrombosis responses to
HEPA filtration across and within four subgroups of male or female and Hispanic or non-Hispanic participants.
We will leverage the diverse population in Los Angeles to investigate the effect of indoor PM2.5 filtration on both
levels and slopes of change in atherothrombosis biomarkers including arterial stiffness, blood pressure, targeted
proinflammatory and prothrombotic markers, and novel proteomic makers, as well as CVD risk score. The focus
on the slopes of change over time is novel and will provide better prediction of future CVD events and mortality
than biomarker level changes assessed in previous studies. We have an experienced team of investigators at
the University of Southern California (USC) and Duke University and will leverage the rich patient resource from
the USC KECK electronic medical records and the linked census-track PM2.5 data to enroll 100 participants of
65-84 years old non-smokers with a history of ischemic heart disease (clinically stable for at least 6 months) who
have lived in the census track with higher ambient PM2.5 exposure in the past years. Participants will be block-
randomized to two intervention arms (HEPA or sham filtrations, each of 9-month duration) and crossed over to
the other intervention arm after a 3-month washout period. This design allows us to conduct the two intervention
arms in the same calendar months of two consecutive years. Three home visits will be conducted during each
intervention arm to set-up and calibrate air monitors, measure health outcomes, and collect biospecimens.
Lifestyle and health covariates will be collected through online questionnaires. The crossover design and timing-
controlled interventions will reduce the influence of confounding factors since participants serve as their own
controls in the within-person comparison. Indoor and outdoor PM2.5 and co-pollutants will be measured; and
meteorological data as well as wildfire events will be recorded throughout the trial. These covariates will be
adjusted for in the statistical analyses. Our aims match the goal of NOT-HL-20-788 calling feasibility trials to
investigate the effects of portable air cleaners on reducing PM2.5 exposure and CVD biomarkers including novel
omics markers. Findings of the proposed study will provide the efficacy and feasibility data to support future
nationwide or multi-center trials to further investigate the air filtration effect on adverse CVD event incidence and
mortality.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zhanghua Chen其他文献
Zhanghua Chen的其他文献
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{{ truncateString('Zhanghua Chen', 18)}}的其他基金
Circulating levels of Persistent Organic Pollutants and Subclinical Atherosclerosis progression in Postmenopausal women
持久性有机污染物的循环水平和绝经后妇女亚临床动脉粥样硬化进展
- 批准号:
10707102 - 财政年份:2022
- 资助金额:
$ 65.66万 - 项目类别:
HEPA Filtration on Reducing Cardiometabolic Risk During Wildfires
HEPA 过滤可降低野火期间的心脏代谢风险
- 批准号:
10838186 - 财政年份:2022
- 资助金额:
$ 65.66万 - 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
- 批准号:
10256678 - 财政年份:2020
- 资助金额:
$ 65.66万 - 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
- 批准号:
10653028 - 财政年份:2020
- 资助金额:
$ 65.66万 - 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
- 批准号:
10450096 - 财政年份:2020
- 资助金额:
$ 65.66万 - 项目类别:
Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes
空气污染、肥胖和糖尿病之间的代谢组学特征
- 批准号:
9920725 - 财政年份:2017
- 资助金额:
$ 65.66万 - 项目类别:
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