Slowing Atherothrombosis Progression through Indoor Air Filtration: A Crossover Trial in Hispanic and non-Hispanic Adults with Ischemic Heart Disease History

通过室内空气过滤减缓动脉粥样硬化血栓形成的进展:对有缺血性心脏病史的西班牙裔和非西班牙裔成年人进行的交叉试验

基本信息

  • 批准号:
    10688095
  • 负责人:
  • 金额:
    $ 65.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the US. There has been an increasing recognition of the important contribution of fine particulate pollution (PM2.5) to CVD morbidity and mortality. Mounting evidence suggests that the use of indoor air filtration to reduce PM2.5 exposure from days to weeks leads to improvement in acute atherothrombosis biomarkers. However, no trials have assessed whether these short-term effects are sustained or further improved with prolonged filtration. The proposed study is the longest intervention trial investigating the effect of using low-cost air purifiers in residences on ameliorating atherothrombosis progressions in vulnerable individuals. The study will examine atherothrombosis responses to HEPA filtration across and within four subgroups of male or female and Hispanic or non-Hispanic participants. We will leverage the diverse population in Los Angeles to investigate the effect of indoor PM2.5 filtration on both levels and slopes of change in atherothrombosis biomarkers including arterial stiffness, blood pressure, targeted proinflammatory and prothrombotic markers, and novel proteomic makers, as well as CVD risk score. The focus on the slopes of change over time is novel and will provide better prediction of future CVD events and mortality than biomarker level changes assessed in previous studies. We have an experienced team of investigators at the University of Southern California (USC) and Duke University and will leverage the rich patient resource from the USC KECK electronic medical records and the linked census-track PM2.5 data to enroll 100 participants of 65-84 years old non-smokers with a history of ischemic heart disease (clinically stable for at least 6 months) who have lived in the census track with higher ambient PM2.5 exposure in the past years. Participants will be block- randomized to two intervention arms (HEPA or sham filtrations, each of 9-month duration) and crossed over to the other intervention arm after a 3-month washout period. This design allows us to conduct the two intervention arms in the same calendar months of two consecutive years. Three home visits will be conducted during each intervention arm to set-up and calibrate air monitors, measure health outcomes, and collect biospecimens. Lifestyle and health covariates will be collected through online questionnaires. The crossover design and timing- controlled interventions will reduce the influence of confounding factors since participants serve as their own controls in the within-person comparison. Indoor and outdoor PM2.5 and co-pollutants will be measured; and meteorological data as well as wildfire events will be recorded throughout the trial. These covariates will be adjusted for in the statistical analyses. Our aims match the goal of NOT-HL-20-788 calling feasibility trials to investigate the effects of portable air cleaners on reducing PM2.5 exposure and CVD biomarkers including novel omics markers. Findings of the proposed study will provide the efficacy and feasibility data to support future nationwide or multi-center trials to further investigate the air filtration effect on adverse CVD event incidence and mortality.
摘要 心血管疾病(CVD)是美国的主要死亡原因。日益增加 认识到细颗粒物污染(PM2.5)对CVD发病率和死亡率的重要贡献。 越来越多的证据表明,使用室内空气过滤,以减少PM2.5暴露从几天到几周, 导致急性动脉粥样硬化血栓形成生物标志物的改善。然而,没有试验评估这些 短期效果持续或随着延长的过滤而进一步改善。拟议的研究是最长的 在住宅中使用低成本空气净化器对改善 动脉粥样硬化血栓形成的进展在脆弱的个人。这项研究将检查动脉粥样硬化血栓形成反应, 在男性或女性以及西班牙裔或非西班牙裔参与者的四个亚组中进行HEPA过滤。 我们将利用洛杉矶不同的人口来研究室内PM2.5过滤对这两个方面的影响。 动脉粥样硬化血栓形成生物标志物(包括动脉僵硬度、血压、靶向 促炎和促血栓形成标志物,和新的蛋白质组标志物,以及CVD风险评分。重点 在随时间变化的斜率上是新颖的,并将提供对未来CVD事件和死亡率的更好预测 生物标志物水平的变化在以前的研究中评估。我们有一支经验丰富的调查团队, 南加州大学(USC)和杜克大学,并将利用丰富的患者资源,从 南加州大学KECK电子病历和相关的人口普查跟踪PM2.5数据,以招募100名参与者, 65-84岁非吸烟者,有缺血性心脏病史(临床稳定至少6个月), 在过去几年中,居住在人口普查轨道上的环境PM2.5暴露较高。参与者将被封锁- 随机分配至两个干预组(HEPA或假过滤,各持续9个月),并交叉至 另一个干预组在3个月的洗脱期后。这种设计使我们能够进行两次干预 在连续两年的同一个日历月内,期间将进行三次家访, 建立和校准空气监测器、测量健康结果和收集生物标本干预部门。 将通过在线问卷收集生活方式和健康协变量。交叉设计和时机- 控制干预将减少混杂因素的影响,因为参与者作为自己的 在人与人之间的比较中。测量室内外PM2.5和混合污染物;以及 气象数据和野火事件将在整个试验过程中记录。这些协变量将是 在统计分析中进行了调整。我们的目标符合NOT-HL-20-788要求可行性试验的目标, 研究便携式空气净化器对减少PM2.5暴露和CVD生物标志物的影响,包括新的 组学标记。拟议研究的结果将提供有效性和可行性数据,以支持未来的 全国性或多中心试验,以进一步研究空气过滤对不良CVD事件发生率的影响, mortality.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Zhanghua Chen其他文献

Zhanghua Chen的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Zhanghua Chen', 18)}}的其他基金

Circulating levels of Persistent Organic Pollutants and Subclinical Atherosclerosis progression in Postmenopausal women
持久性有机污染物的循环水平和绝经后妇女亚临床动脉粥样硬化进展
  • 批准号:
    10707102
  • 财政年份:
    2022
  • 资助金额:
    $ 65.66万
  • 项目类别:
HEPA Filtration on Reducing Cardiometabolic Risk During Wildfires
HEPA 过滤可降低野火期间的心脏代谢风险
  • 批准号:
    10838186
  • 财政年份:
    2022
  • 资助金额:
    $ 65.66万
  • 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
  • 批准号:
    10256678
  • 财政年份:
    2020
  • 资助金额:
    $ 65.66万
  • 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
  • 批准号:
    10653028
  • 财政年份:
    2020
  • 资助金额:
    $ 65.66万
  • 项目类别:
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational Diabetes
妊娠期间和妊娠后持久性有机污染物暴露对妊娠合并妊娠糖尿病女性代谢下降的长期影响
  • 批准号:
    10450096
  • 财政年份:
    2020
  • 资助金额:
    $ 65.66万
  • 项目类别:
Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes
空气污染、肥胖和糖尿病之间的代谢组学特征
  • 批准号:
    9920725
  • 财政年份:
    2017
  • 资助金额:
    $ 65.66万
  • 项目类别:

相似海外基金

Un/kindness, shame & resistance: the care of inpatients in NHS adult acute mental health units and how it might be improved
Un/善良,羞耻
  • 批准号:
    2885806
  • 财政年份:
    2023
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Studentship
Post-Acute Care Transitions for Older Adult Medicare Beneficiaries with Serious Mental Illness
患有严重精神疾病的老年医疗保险受益人的急性后护理过渡
  • 批准号:
    10772386
  • 财政年份:
    2023
  • 资助金额:
    $ 65.66万
  • 项目类别:
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
  • 批准号:
    474619
  • 财政年份:
    2022
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Operating Grants
Investigating the impact acute inhalation of cannabis with a high content of delta-9-tetrahydrocannabinol has on myelination and microglia in adult and aged mice
研究急性吸入高含量 delta-9-四氢大麻酚的大麻对成年和老年小鼠髓鞘形成和小胶质细胞的影响
  • 批准号:
    485965
  • 财政年份:
    2022
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Studentship Programs
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
  • 批准号:
    466358
  • 财政年份:
    2022
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Operating Grants
Metabolomics for prediction of cisplatin mediated acute kidney injury: a Canadian multi-centre adult and pediatric study
预测顺铂介导的急性肾损伤的代谢组学:加拿大多中心成人和儿童研究
  • 批准号:
    402040
  • 财政年份:
    2019
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Operating Grants
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
  • 批准号:
    18K16103
  • 财政年份:
    2018
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Causal effect of time-varying driving pressures on mortality in mechanically ventilated, adult patients with acute respiratory distress syndrome
时变驱动压力对机械通气成年急性呼吸窘迫综合征患者死亡率的因果影响
  • 批准号:
    377313
  • 财政年份:
    2017
  • 资助金额:
    $ 65.66万
  • 项目类别:
    Studentship Programs
Role of SETBP1 in adult Ph+ acute lymphoblastic leukemia
SETBP1 在成人 Ph 急性淋巴细胞白血病中的作用
  • 批准号:
    9315111
  • 财政年份:
    2016
  • 资助金额:
    $ 65.66万
  • 项目类别:
Acute Inhibition of Adult-born Granule Cells and its Effect on Antidepressant Act
成体颗粒细胞的急性抑制及其抗抑郁作用
  • 批准号:
    8734273
  • 财政年份:
    2013
  • 资助金额:
    $ 65.66万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了