fMRI Study on the Common Abnormal Neural Circuitry in Schizophrenia and Epileptic Psychosis

据报道，异常自愿眼球运动是精神分裂症的遗传易感性标志。我们已经研究了大脑激活模式，在执行各种眼动任务，以阐明异常的神经回路精神分裂症使用功能磁共振成像。我们还调查了癫痫性精神病患者，其症状与精神分裂症患者相似，以澄清是否相同的神经回路受到影响。本研究获得了日本大学医学部伦理委员会的批准。在充分解释实验程序后，获得所有参与者的书面知情同意书。受试者为21名正常对照（11名男性/ 10名女性，平均年龄39.2±10.2岁），18名精神分裂症患者（12/ 6，34.8±8.5岁）和5名癫痫性精神病患者（5/ 0，34.8±14.4岁）。使用1.5特斯拉临床MRI扫描仪，用梯度回忆EPI获取脑成像数据以获得BO ...更多信息 LD对比度涵盖整个大脑（TR 4000 ms，TE 62 ms，像素大小3.0×3.0 mm，切片数40，FOV 192 mm，矩阵64×64，翻转角90 °，切片厚度3 mm）。眼动仪用于任务显示和眼动监测。每个受试者进行五个系列，在40秒的四眼运动任务（扫视、反扫视、平滑追踪眼运动、具有注意力增强程序的SPEM任务）和40秒的基线（注视）之间交替。图像分析采用SPM 99随机效应分析，未校正的P<0.001，聚类水平校正的P<0.05。与正常对照组相比，精神分裂症和癫痫性精神病患者在视觉引导扫视任务时额叶功能低下或无效，在反扫视任务时纹状体-丘脑功能低下。因此，这些发现可能归因于精神病状态。另一方面，在平稳追踪眼动任务中，注意增强程序仅在精神分裂症中发现右半球低激活。目前的研究结果是根据证据异常半球偏侧精神分裂症，已报告最近的功能磁共振成像研究使用各种语言任务。少

The abnormal voluntary eye movements are reported to be a genetic vulnerability marker for schizophrenia. We have studied brain activation patterns during performing various eye movement tasks to elucidate abnormal neural circuitry for schizophrenia using functional MRI. We have also investigated the patients with epileptic psychosis, whose symptoms are similar to those with schizophrenia, to clarify whether the same neural circuit is affected or not. This research obtained the approval from the ethical committee of Nihon University School of Medicine. Written informed consent was obtained from all the participants after the procedure of the experiments was fully explained. The subjects were 21 normal controls (11 males/ 10 females, mean age 39.2±10.2 yrs), 18 patients with schizophrenia (12/ 6, 34.8±8.5 yrs), and five patients with epileptic psychosis (5/ 0, 34.8±14.4 yrs). Using a 1.5 Tesla clinical MRI scanner, brain imaging data were acquired with gradient-recalled EPI to obtain BO … More LD contrast encompassing the entire brain (TR 4000ms, TE 62ms, pixel size 3.0×3.0 mm, number of slices 40, FOV 192 mm, matrix 64×64, flip angle 90 deg, slice thickness 3 mm). An eye tracking instrument was used for task display and eye movement monitoring. Each subject performed five series alternating between 40 sec of four eye movement task (saccade, anti-saccade, smooth pursuit eye movement, SPEM task with attention enhancement procedure) and 40 sec of baseline (fixation). Image analysis was performed using SPM99with random-effect analysis at a significant level of uncorrected p<0.001 and cluster level corrected p<0.05.Compared with normal controls, low capacity or inefficiency in frontal function during visually-guided saccade task and striate-thalamic hypo-activation during anti-saccade task was found both in schizophrenia and epileptic psychosis. Therefore, these findings may be attributable to psychotic state. On the other hand, right hemisphere hypo-activation during smooth pursuit eye movement task with attention enhanced procedure was found only in schizophrenia. The present results are in accordance with the evidence for abnormal hemispherical laterality in schizophrenia, that have been reported by recent fMRI studies using various language tasks. Less