fMRI Study on the Common Abnormal Neural Circuitry in Schizophrenia and Epileptic Psychosis

精神分裂症和癫痫性精神病常见神经回路异常的功能磁共振成像研究

• 批准号: 14570946
• 负责人: MATSUURA Masato
• 金额: $ 2.24万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570946/
• 关键词: Functional MRI; Schizophrenia; Epileptic psychosis; Eye movements; Neural circuitry; Hypofrontality; Striato-thalamic hypoactivity; Right hemisphere hypoactivity; 脳内神経回路異常; 追跡眼球運動; アンチサッケード; 探索眼球運動; 前頭葉・基底核・視床回路; 前頭葉機能低下

The abnormal voluntary eye movements are reported to be a genetic vulnerability marker for schizophrenia. We have studied brain activation patterns during performing various eye movement tasks to elucidate abnormal neural circuitry for schizophrenia using functional MRI. We have also investigated the patients with epileptic psychosis, whose symptoms are similar to those with schizophrenia, to clarify whether the same neural circuit is affected or not. This research obtained the approval from the ethical committee of Nihon University School of Medicine. Written informed consent was obtained from all the participants after the procedure of the experiments was fully explained. The subjects were 21 normal controls (11 males/ 10 females, mean age 39.2±10.2 yrs), 18 patients with schizophrenia (12/ 6, 34.8±8.5 yrs), and five patients with epileptic psychosis (5/ 0, 34.8±14.4 yrs). Using a 1.5 Tesla clinical MRI scanner, brain imaging data were acquired with gradient-recalled EPI to obtain BO … More LD contrast encompassing the entire brain (TR 4000ms, TE 62ms, pixel size 3.0×3.0 mm, number of slices 40, FOV 192 mm, matrix 64×64, flip angle 90 deg, slice thickness 3 mm). An eye tracking instrument was used for task display and eye movement monitoring. Each subject performed five series alternating between 40 sec of four eye movement task (saccade, anti-saccade, smooth pursuit eye movement, SPEM task with attention enhancement procedure) and 40 sec of baseline (fixation). Image analysis was performed using SPM99with random-effect analysis at a significant level of uncorrected p<0.001 and cluster level corrected p<0.05.Compared with normal controls, low capacity or inefficiency in frontal function during visually-guided saccade task and striate-thalamic hypo-activation during anti-saccade task was found both in schizophrenia and epileptic psychosis. Therefore, these findings may be attributable to psychotic state. On the other hand, right hemisphere hypo-activation during smooth pursuit eye movement task with attention enhanced procedure was found only in schizophrenia. The present results are in accordance with the evidence for abnormal hemispherical laterality in schizophrenia, that have been reported by recent fMRI studies using various language tasks. Less

据报道，异常的自愿眼球运动是精神分裂症的遗传易感性标志。我们研究了在执行各种眼动任务时的大脑激活模式，利用功能性磁共振成像来阐明精神分裂症的异常神经回路。我们还调查了癫痫性精神病患者，其症状与精神分裂症患者相似，以澄清是否相同的神经回路受到影响。本研究获得日本大学医学院伦理委员会批准。在充分解释实验过程后，获得所有参与者的书面知情同意。正常对照21例（男11例，女10例，平均年龄39.2±10.2岁），精神分裂症患者18例（12/ 6,34.8±8.5岁），癫痫性精神病患者5例（5/ 0,34.8±14.4岁）。使用1.5特斯拉临床MRI扫描仪，使用梯度召回EPI获取脑成像数据，获得覆盖全脑的BO…More LD对比度（TR 4000ms, TE 62ms，像素尺寸3.0×3.0 mm，切片数40，FOV 192 mm，矩阵64×64，翻转角度90度，切片厚度3 mm）。使用眼动仪进行任务显示和眼动监测。每个被试在40秒四眼动任务（扫视、反扫视、平滑追求眼动、带注意增强程序的SPEM任务）和40秒基线（注视）之间交替进行5个系列。使用spm99进行图像分析，随机效应分析在未校正的显著水平p<0.001，聚类水平校正p<0.05。与正常对照相比，精神分裂症和癫痫性精神病患者在视觉引导下的扫视任务中均存在额叶功能低容量或低效率，在抗扫视任务中均存在纹状丘脑低激活。因此，这些发现可能归因于精神状态。另一方面，仅在精神分裂症患者中发现了平滑追逐眼动任务中右半球低激活的现象。目前的结果与精神分裂症中半球偏侧异常的证据一致，这是最近使用各种语言任务的功能磁共振成像研究所报道的。少

项目成果

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Ohtsuki T、Tanaka S、Ishiguro H 等人：“未能发现 PRODH 缺失与精神分裂症之间的关联”Schizophr Res。

Matsuura M, Adachi N, Oana Y, et al.: "A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders."Schizophr Res. (in press). (2004)

Matsuura M、Adachi N、Oana Y 等人：“癫痫性精神病和精神分裂症谱系障碍的多诊断和维度比较。”Schizophr Res。

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Matsuda T、Matsuura M、Ohkubo T 等人：“视觉引导扫视和反扫视期间大脑激活的功能 MRI 映射：皮层皮层下网络”精神病学研究：神经影像学。

Matsuura M, Adachi N, Oana Y, et al.: "Polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders"Schizophr Res. (in press). (2004)

Matsuura M、Adachi N、Oana Y 等人：“癫痫性精神病和精神分裂症谱系障碍的多诊断和维度比较”Schizophr Res。

Matsuura M et al.: "A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders"Schizophrenia Research. (In press). (2003)

Matsuura M 等人：“癫痫性精神病和精神分裂症谱系障碍的多诊断和维度比较”精神分裂症研究。