Using integrated omics to identify dysfunctional genetic mechanisms influencing schizophrenia and sleep disturbances

使用整合组学来识别影响精神分裂症和睡眠障碍的功能失调的遗传机制

基本信息

  • 批准号:
    10770880
  • 负责人:
  • 金额:
    $ 25.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-02-01 至 2024-04-14
  • 项目状态:
    已结题

项目摘要

The proposed work aims to decipher genetic factors dysregulated in the brains of individuals with schizophrenia with pleiotropic effects influencing sleep issues. The goals are to inform genomic driven medical care for improved treatment of sleep problems, which are among the most common co-occurring conditions in these patients. Sleep disruptions are associated with more severe schizophrenia-related symptoms. Healthy sleep is important for neurodevelopment, indicating that managing sleep disturbances may have significant impacts on reducing severity of schizophrenia symptoms and improving long-term outcomes. Characterizing pleiotropic genetic effects using multiomics data holds promise for informing precision medicine approaches to treatment of sleep problems in these individuals. Investigators at the University of Kansas Medical Center have whole brain specimens from human donors diagnosed with schizophrenia and confirmed controls. This brain bank reflects a diverse collection of specimens from males and females with different reported race. This project will generate multi-omics data from sleep-wake regulating brain regions in these specimens and identify genetic variation impacting function of pleiotropic genes and proteins evidenced to increase risk for both schizophrenia and insomnia-related symptoms. Variants with evidence for pharmacogenetic and regulatory effects on genes encoding drug targets will be evaluated. Genetic risk scores calculated from sequence data that are useful to predicting risk and aiding in early detection and intervention will be functionally validated. In addition, this project will comprehensively characterize gene and protein coexpression connecting two important brain regions known to regulate human sleep behaviors. Combining evidence from the genome, transcriptome and proteome will allow for discerning the biochemical pathways and genetic mechanisms dysregulated in sleep-wake regulating brain regions from these patients and help identify proteins that can be targeted by small molecule compounds to treat sleep problems more effectively. This work should also provide knowledge of how convergent mechanisms influence risk for multiple disorders in the same individual. The approaches developed and data generated in this project will provide a rich resource that will be shared with the larger scientific community allowing for investigations of the sleep regulation network in a diverse representation of individuals with mental health conditions.
提出的工作旨在破译遗传因素失调的个体的大脑有

项目成果

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Steven Allan Soper其他文献

Steven Allan Soper的其他文献

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{{ truncateString('Steven Allan Soper', 18)}}的其他基金

Detection of MRD in TNBC Through Multi-Platform Molecular Biomarker Analysis
通过多平台分子生物标志物分析检测 TNBC 中的 MRD
  • 批准号:
    10580880
  • 财政年份:
    2022
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biomedical Engineering Core
生物医学工程核心
  • 批准号:
    10115111
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biomedical Engineering Core
生物医学工程核心
  • 批准号:
    10582672
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
Facilitating a Multi-Institutional Enterprise
促进多机构企业
  • 批准号:
    10172700
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis
规模感:使用混合规模系统进行稀有生物标志物分析
  • 批准号:
    10493147
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine
精准医学生物模块化多尺度系统(CBM2)生物技术资源中心
  • 批准号:
    10693387
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine
精准医学生物模块化多尺度系统(CBM2)生物技术资源中心
  • 批准号:
    10493122
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale Electrophoresis
单分子处理:使用固定化纳米级酶反应器 (INER) 和纳米级电泳检测和鉴定单个 DNA、RNA 和蛋白质
  • 批准号:
    10493128
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biotechnology Resource Center of Biomodular Multi scale Systems CBM2 for Precision Molecular Diagnostics
用于精密分子诊断的生物模块化多尺度系统 CBM2 生物技术资源中心
  • 批准号:
    9404585
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:
Biotechnology Resource Center of Biomodular Multi scale Systems CBM2 for Precision Molecular Diagnostics
用于精密分子诊断的生物模块化多尺度系统 CBM2 生物技术资源中心
  • 批准号:
    8935077
  • 财政年份:
    2015
  • 资助金额:
    $ 25.5万
  • 项目类别:

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Improving the quality and coherence of biochemical pathway information resources and developing tools to facilitate the investigation of intestinal microflora
提高生化途径信息资源的质量和一致性,开发促进肠道微生物群研究的工具
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MouseCyc: A Biochemical Pathway Database for the Mouse
MouseCyc:小鼠生化通路数据库
  • 批准号:
    7351830
  • 财政年份:
    2006
  • 资助金额:
    $ 25.5万
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MouseCyc: A Biochemical Pathway Database for the Mouse
MouseCyc:小鼠生化通路数据库
  • 批准号:
    7033357
  • 财政年份:
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