Neointimal formation in the earotid artery of in IP3^R knock out mouse

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Vascular remodeling with neointimal formation was studied in 1P3-R knock out mouse. IP3-R type1 hetero knock out mouse (n=10)、 IP-3 type2 homo knock out mouse (n=9)、 IP-3 type3 homo knock out mouse (n=11) and control mouse (n=10) were used in the carotid ligation model. The animals were anesthetized, and the left common carotid artery was exposed through a small midline incision in the neck. The artery was completely ligated just proximal to the carotid bifurcation to disrupt blood flow. Left carotids were snap-frozen at days 28 after ligation. Neointima area/medial area ratio was calculated. The maximum ratio of IP3-type1 and type2 homo knock out mouse group was significantly smaller than that of control. The average ratio of IP-3 type2 and type3 homo knock out mouse group was significantly smaller than that of control. In this study, intimal hyperplasia in the carotid ligation model was suppressed in IP3-R knockout mouse.