Antioxidant Agents Therapy for Esophageal Mucosa with Inducible Nitric Oxide Syntlaase Expression

抗氧化剂治疗具有诱导型一氧化氮合酶表达的食管粘膜

• 批准号: 14571230
• 负责人: TANAKA Hikaru
• 金额: $ 1.6万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571230/
• 关键词: esophageal carcinoma; rat; iNOS; anthocyanins; curemin; sesamin

2002 : We made the antioxidation feed which mixed blueberry (anthocyanins)10% sesame (sesamin) 10%, turmeric (curumin)10% with each. It was given the group of treatments rat N-Methyl-N-anyhtitrosamine (following AMN) since administered antioxidation feed for one week. The crowd whom administered antioxidation feed and AMN to and the control crowd whom administered normal feed and ANN to administered it with 12 weeks for ten weeks for each eight weeks, and sacrifice was made to die. The appearance of iNOS was accepted in eight weeks, but cancer-Causing frequency was held down. For ten weeks, carcinogenesis was accepted in 12 weeks by all rats. As the intake situation of antioxidation feed, some feed with turmeric bit it and remained in a bottom of a gauge in large quantities, and it was thought that there were not most of the effects of turmeric, but when continued administering a cancer-causing agent together, a carcinogenesis prevention effect by quality of these antioxides might dela … More y carcinogenesis temporarily, but that the effect that completely controlled carcinogenesis was not provided was supposed.2003 : We analyzed a study result of 2002 again. If we did carcinogenesis entirely in eight weeks and bred it by the dosage for eight weeks in conventional AMN afterwards until 12 weeks, careinogenesis of 100% was the provided situation and, with a rat of control, was different from the time that the cancer-causing time by AMN thought about at first greatly. Because AMN which we used conventionally purchased AMN from an other chemical reagent company because release was called off, it is thought that the cancer-causing time changed by a difference of purity of AMN. A rat carcinogenesis experiment by AMN was cancer-causing experiment system developed in this institution and there was not a document and added enough examination besides conventional accumulation data about the dosage density and a dosage period of AMN. Now do cancer-causing fundamental experiment between the dosage period of AMN for six weeks for five weeks for four weeks for two weeks.1 set the result between the dosage period for the cause again and am to administer AMN to a special feed dosage rat. Less

2002年：将蓝莓(花青素)10%、芝麻(芝麻素)10%、姜黄素(姜黄素)10%分别混合制成抗氧化饲料。从给予抗氧化饲料开始，给予治疗组大鼠N-甲基-N-氨基三胺(以下简称AMN)1周。给予抗氧化剂饲料和AMN的大鼠和给予普通饲料和ANN的对照组大鼠给予12周，10周，每8周一次，处死动物。INOS的出现在8周内被接受，但致癌频率被抑制。连续10周，所有大鼠在12周内接受致癌。由于抗氧化剂的摄入情况，有些饲料用姜黄咬了一下，大量留在了量规的底部，人们认为姜黄没有大部分的作用，但当继续服用一种致癌剂时，这些抗氧化剂的质量防癌作用可能会降低…暂时性致癌较多，但推测未提供完全控制致癌的作用。2003：我们重新分析了2002年的一项研究结果。如果在8周内完全致癌，然后在常规AMN中按剂量饲养8周，直到12周，则100%的致癌率是提供的情况，并且与对照大鼠的致癌时间相比，AMN最初考虑的致癌时间有很大的不同。由于我们使用的AMN通常是从其他化学试剂公司购买的，因为释放被取消了，所以人们认为致癌时间是由于AMN纯度的不同而改变的。AMN的大鼠致癌实验是本所自行研制的致癌实验系统，除了常规积累的AMN剂量密度和给药周期数据外，尚无文献，增加了足够的检验。现在进行致癌基础实验，AMN的剂量周期为6周、5周、4周、2周。1将结果设置为再次致癌的剂量周期和AM给特定饲料剂量的大鼠之间的结果。较少