Antioxidant Agents Therapy for Esophageal Mucosa with Inducible Nitric Oxide Syntlaase Expression

抗氧化剂治疗具有诱导型一氧化氮合酶表达的食管粘膜

• 批准号: 14571230
• 负责人: TANAKA Hikaru
• 金额: $ 1.6万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571230/
• 关键词: esophageal carcinoma; rat; iNOS; anthocyanins; curemin; sesamin

2002 : We made the antioxidation feed which mixed blueberry (anthocyanins)10% sesame (sesamin) 10%, turmeric (curumin)10% with each. It was given the group of treatments rat N-Methyl-N-anyhtitrosamine (following AMN) since administered antioxidation feed for one week. The crowd whom administered antioxidation feed and AMN to and the control crowd whom administered normal feed and ANN to administered it with 12 weeks for ten weeks for each eight weeks, and sacrifice was made to die. The appearance of iNOS was accepted in eight weeks, but cancer-Causing frequency was held down. For ten weeks, carcinogenesis was accepted in 12 weeks by all rats. As the intake situation of antioxidation feed, some feed with turmeric bit it and remained in a bottom of a gauge in large quantities, and it was thought that there were not most of the effects of turmeric, but when continued administering a cancer-causing agent together, a carcinogenesis prevention effect by quality of these antioxides might dela … More y carcinogenesis temporarily, but that the effect that completely controlled carcinogenesis was not provided was supposed.2003 : We analyzed a study result of 2002 again. If we did carcinogenesis entirely in eight weeks and bred it by the dosage for eight weeks in conventional AMN afterwards until 12 weeks, careinogenesis of 100% was the provided situation and, with a rat of control, was different from the time that the cancer-causing time by AMN thought about at first greatly. Because AMN which we used conventionally purchased AMN from an other chemical reagent company because release was called off, it is thought that the cancer-causing time changed by a difference of purity of AMN. A rat carcinogenesis experiment by AMN was cancer-causing experiment system developed in this institution and there was not a document and added enough examination besides conventional accumulation data about the dosage density and a dosage period of AMN. Now do cancer-causing fundamental experiment between the dosage period of AMN for six weeks for five weeks for four weeks for two weeks.1 set the result between the dosage period for the cause again and am to administer AMN to a special feed dosage rat. Less

2002年：我们制作了抗氧化饲料，将蓝莓（花青素）混合10％芝麻（芝麻蛋白）10％，姜黄（Curumin）的抗氧化剂10％，每种姜黄（Curumin）10％。它被给予了一组治疗大鼠N-甲基N-甲甲胺（随后），因为施用了抗氧化饲料一周。管理抗氧化饲料和AMN的人群，以及控制正常的饲料和ANN的控制人群，每八周以12周的时间对其进行管理，并牺牲了死亡。 iNOS的出现在八周内被接受，但降低了引起癌症的频率。十个星期，所有大鼠在12周内接受致癌作用。随着抗氧化饲料的摄入状况，有些用姜黄喂食并留在量规的底部，并被认为没有大多数姜黄的作用，但是当继续将引起癌症的药物施用时，癌变的预防效果会导致这些抗Xides的质量预防效果，这些抗氧化物的质量可能会产生更多的效果。 ：我们再次分析了2002年的研究结果。如果我们完全在八周内进行了致癌作用，并且随后在常规AMN中通过剂量将其繁殖了八周，那么100％的CareInogenesis（100％的CareInegenes）就是提供的情况，并且由于一大鼠的控制，与AMN的癌症引起癌症的时间不同。因为我们使用的AMN使用常规的AMN从另一家化学试剂公司购买的AMN，因为释放被释放，因此人们认为，由于AMN的纯度差异，引起癌症的时间改变了。 AMN进行的大鼠致癌实验是该机构中开发的致癌实验系统，除了有关剂量密度和AMN剂量时期的常规积累数据外，还没有足够的检查。现在，在AMN的剂量周期之间进行癌症的基本实验六个星期，持续五周，持续四个星期。1设置该原因的剂量期之间的结果，并向特殊的饲料剂量大鼠施用AMN。较少的