Comparative investigation of tolerance trait of anticancer drugs in primary and metastatic lesions of gastrointestinal carcinoma

胃肠道癌原发灶与转移灶抗癌药物耐受性的比较研究

• 批准号: 14571235
• 负责人: OGAWA Kenji
• 金额: $ 2.11万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571235/
• 关键词: Cancer Chemotherapy; Metastasis; Embrane Transporter; DNA repair; Angiogenesis; GI tract carcinoma

First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (XPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RT-PCR and immunohistochemical analysis. The expression levels of TP and TS were different between primary and metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in animal models. Unfortunately, the enhancement of these molecules was not obtained.

首先，采用RT-PCR和免疫组化方法检测肿瘤化疗靶分子如药物转运蛋白（ATP 7 B、MRP 2）、DNA修复分子（XPG、XPF）和化疗靶分子TP、DPD、TS的表达水平。TP和TS在原发灶和转移灶中的表达水平不同。接下来，使用TS或TP的转染子，在动物模型中检查这些分子的表达水平的增强。不幸的是，没有获得这些分子的增强。

项目成果

Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma

铜转运P型三磷酸腺苷酶（ATP7B）在人肝细胞癌中的表达

• 发表时间: 2004
• 期刊: Anticancer Res. 24
• 作者: Ogawa K.;Sugeno H.;Takebayashi Y.;Higashimoto M.;Ogura Y.;Shibukawa G.;Kanzaki A.;Terada K.;Sugiyama T.;Watanabe K.;Katoh R.;Nitta Y;Fukushima T.;Koyama Y.;Inoue N.;Sekikawa K.;Sato Y.;Takenoshita S.
• 通讯作者: Takenoshita S.

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