Involvement of COX-2 and free radical-related enzymes in the malignant transformation of ovarian endometrial cyst

◇超氧化物歧化酶在子宫内膜腺癌组织中的免疫组化表达研究：(1)Cu/Zn-SOD在子宫内膜腺癌组织中的表达分布；(2)不同组织学类型的表达差异；(3)表达强度对患者生存率的影响。与正常子宫内膜相比，在子宫内膜癌中，特别是在透明细胞腺癌中，Cu/Zn-SOD的表达更强。提示Cu/Zn-SOD表达可能与子宫内膜腺癌的初始致癌因素有关。◇环氧合酶-2与卵巢巧克力囊肿和卵巢癌的关系：卵巢巧克力囊肿中的表达明显高于对照组。在卵巢癌组中，子宫内膜样型染色最高，其次为透明细胞型和浆液型。在大多数卵巢巧克力囊肿和卵巢癌病例中，COX-2在细胞质中呈弥漫性和颗粒状染色。腺体基底膜和管腔的COX-2染色定位无差异。综上所述，COX-2过表达可能复杂地参与卵巢巧克力囊肿的恶性转化。

◇Immunohistochemical expression of superoxide dismutase in endometrial adenocarcinomaThis study examined : (1)the distribution of Cu/Zn-SOD expression in endometrial adenocarcinomas ; (2)differences in this expression based on histological type ; and (3)variations in patient survival rate with intensity of expression.Stronger expression of Cu/Zn-SOD was observed in endometrial carcinomas, particularly in clear cell adenocarcinoma, when compared to normal endometrium. This suggests that Cu/Zn-SOD expression might be correlated with initial carcinogenetic factor of the endometrial adenocarcinoma.◇Involvement of Cyclooxygenase-2 in Ovarian Chocolate Cyst and Ovarian Cancerthe expression in ovarian chocolate cyst revealed significantly higher than that of the control. Among the groups of ovarian carcinoma, the highest staining was found in endometrioid type, followed by clear cell type and serous type. In the majority of ovarian chocolate cyst and ovarian cancer cases, COX-2 was diffusely and granularly stained in cytoplasm. No difference in the localization of COX-2 staining was seen between the basement membrane and the lumen of glands. In conclusion, overexpression of COX-2 may be intricately involved in malignant transformation of ovarian chocolate cysts.