Mechanisms of postoperative pain after laparotomy

剖腹手术后疼痛的机制

• 批准号: 22791422
• 负责人: TANAKA Hidenori
• 金额: $ 2.5万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791422/
• 关键词: 開腹手術; 脊髄; 術後痛

The purpose of the present study was to investigate the mechanisms of postoperative pain after laparotomy. Skin and muscle plus peritoneum incision on the rat abdomen(group P) markedly reduced spontaneous movements and increased the incidence of pain-related behaviors compared with skin and muscle incision(group S). Spontaneous activities of thoracic dorsal horn neurons in group P significantly increased, whereas they did not change in group S. The changes in behavioral and electrophysiological experiments in group P were inhibited by intrathecal administration of NMDA receptor antagonists.

本研究的目的是探讨剖腹手术后疼痛的机制。与皮肤肌肉切口（S组）相比，大鼠腹部皮肤肌肉加腹膜切口（P组）显着减少自发运动，增加疼痛相关行为的发生率。 P组胸背角神经元自发活动显着增加，而S组无变化。鞘内注射NMDA受体拮抗剂可抑制P组行为学和电生理实验的变化。

项目成果

Behavioral characterization of a newly developed model of postoperative pain after laparotomy

新开发的剖腹术后疼痛模型的行为特征

• 发表时间: 2011
• 作者: Koizuka S;Saito S;Tobe M;Sekimoto K;Obata H and KoyamaY;肥塚史郎;田中秀典
• 通讯作者: 田中秀典

Evaluation of daily physical activity of anesthesiologists and its relation ship to fatigue

麻醉医师日常体力活动评价及其与疲劳的关系

• 发表时间: 2010
• 作者: Eiko Yashiro;Natsuko Nozaki-Taguchi;Shiroh Isono;Takashi Nishino.;黒田昌孝;田中秀典
• 通讯作者: 田中秀典