The bcl-2transcription factors in human endometrium

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The estrogen-estrogen receptor (ER) signalling pathway plays crucial physiologic roles not only in control of reproduction, but also the generation of cancer in breast and uterus. While some ER target genes have been identified containing the estrogen responsive element (ERE), others are activated eventually by estrogen via protein-protein interaction without binding to ERE. In a previous study we found out that the proliferative stage-specific expression of the bcl-2 gene in the glandular cells could be regulated by binding of c-Jun to its motifs in the promoter. Results from the present studies indicate that the menstrual cyclic expression of bcl-2 could be controlled by either the direct binding of ERa to ERE in the c-jun promoter or the interaction with c-Jun that binds to its motifs in the bcl-2 gene. Intriguingly, the transcriptionally active form of c-Jun phosphorylated at Ser73 was identified binding to the identified motifs in a menstrual cycle non-specific manner. Our studies revealed a novel mechanism that transcriptionally regulates the expression of bcl-2 in normal human endometrium.