Molecular investigation on prognostic factors and development of an tailor-made therapy for Hunt syndrome.

1.水痘-带状疱疹病毒DNA水平与Ramsay Hunt综合征面瘫的关系我们探讨了Ramsay Hunt综合征(RHS)患者唾液中水痘-带状疱疹病毒(VZV)拷贝数与临床症状的关系。口咽部带状疱疹患者面部功能恢复较非带状疱疹患者差。唾液中的VZV DNA水平可能反映了RHS患者面神经和口咽上皮中病毒重新激活的动力学。2.Ramsay Hunt综合征中水痘-带状疱疹病毒重新激活的模式我们分析了42例RHS患者VZV载量与面瘫发病的关系。结果表明，面瘫可以发生在VZV复活早期和消退阶段之间的不同时间段，提示VZV复活引起的面神经功能障碍的发展和神经炎的进展有不同的模式。3.静脉曲张…的血清学诊断急性周围性面瘫患者更易出现带状疱疹病毒再激活。我们用酶免疫分析法(EIA)检测血清中抗VZV-Ig G抗体滴度，并探讨了EIA对VZV再激活的诊断标准。对于VZV Ig G EIA抗体滴度双倍升高的病例，诊断为VZV再激活是合适的。Ramsay Hunt综合征患者水痘-带状疱疹病毒载量与前庭症状的关系本研究分析了水痘-带状疱疹病毒载量与耳蜗前庭症状发生的关系。结果表明，从VZV激活的早期到消退阶段，耳蜗前庭症状可以在不同的时间出现，提示VZV重新激活引起的第八脑神经功能障碍的发展和神经炎的进展有多种模式。5.水痘-带状疱疹病毒重新激活是儿童急性周围性面瘫的主要原因。结果表明，VZV激活是儿童急性周围性面瘫的主要原因，尤其是在6-15岁之间。相反，我们的数据表明HSV-1重新激活不是儿童Bell‘s面瘫的主要发病机制。6.分析Bell’s面瘫患者恢复不完全的原因。结果表明，VZV或HSV-1的重新激活是贝尔面瘫的主要原因，预后较差。较少

1.Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndromeWe have investigated whether the copy number of varicella-zoster virus (VZV) in saliva correlates with the clinical symptoms in patients with Ramsay Hunt syndrome (RHS). Patients with oropharyngeal zoster showed worse recovery of facial function than those without. It seems that the VZV DNA level in saliva reflects the kinetics of viral reactivation in the facial nerve as well as in the oropharyngeal epithelium in RHS patients.2.Patterns of varicella-zoster virus reactivation in Ramsay Hunt syndromeWe analyzed the relationship between VZV load and onset of facial paralysis in 42 RHS patients. The results indicate that facial paralysis in RHS can occur at various times between the early and the regression phase of VZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by VZV reactivation and the progression of neuritis.3.Serological diagnosis of varicel … More la-zoster virus reactivation in patients with acute peripheral facial paralysisWe focused on the determination of an anti-VZV IgG antibody liter in sero-diagnosis by using an enzyme immunoassay (EIA) and investigated the diagnostic criteria for VZV reactivation by EIA. It was considered appropriate to give a diagnosis of VZV reactivation for those cases exhibiting a double-fold increasd in the VZV IgG EIA antibody titer.4. Analysis of varicella-zoster virus load and cochleovestibular symptoms in patients with Ramsay Hunt syndromeThe present study analyzed the relationship between VZV load and the onset of the cochleovestibular symptoms. The results indicate that cochleovestibular symptoms can occur in various timing from the early phase to the regression phase of VZV reactivation, suggesting that there are various patterns in the development of the eighth cranial nerve dysfunction caused by VZV reactivation and progression of neuritis.5.Varicella-zoster virus reactivation is the major cause of acute peripheral facial paralysis m childrenThis study analyzed the causes of acute peripheral facial paralysis in children by serological assays and PCR using paired sera and saliva samples. The results indicate that VZV reactivation is the major cause of acute peripheral facial paralysis in children, especially in ages between 6 and 15. In contrast, our data suggest that HSV-1 reactivation is not the major pathogenesis of Bell's palsy in children.6.Analysis of patients with Bell's palsy who showed incomplete recoveryThis study analyzed the causes of clinically diagnosed Bell's palsy who showed incomplete recovery of facial movement. The results indicate that VZV or HSV-1 reactivation is the major cause of Bell's palsy with poor prognosis. Less