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Investigation on the pathogenesis of herpetic facial nerve paralysis

带状疱疹性面神经麻痹发病机制探讨

基本信息

批准号：
16390482
负责人：
FURUTA Yasushi
金额：
$ 6.46万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

1,Patterns of herpes virus reactivation in facial nerve paralysisWe analyzed the relationship between HSV-1NZV load and onset of facial paralysis in patients with facial paralysis. The results indicate that facial paralysis can occur at various times between the early and the regression phase of HSV-1NZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by herpes virus reactivation and the progression of neuritis.2,Gene expression analysis in patients with Bell's palsyGene expression profile was analyzed in patients with Bell's palsy using DNA microarray. We found several genes which were up-or down-regulated at the onset of Bell's palsy.3,Analysis of patients with Bell's palsy who showed incomplete recoveryThis study analyzed the causes of clinically diagnosed Bell's palsy who showed incomplete recovery of facial movement. The results indicate that VZV or HSV-1 reactivation is the major cause of Bell's palsy with poor prognosis … More .4, Prevalence of HSV-1 reactivation in acute peripheral facial paralysisWe analyzed the prevalence of HSV-1 reactivation in acute facial paralysis. The results suggested that in clinically diagnosed Bell's palsy 20% have ZSH and 20% have non-HSVNZV palsy, and the remaining 60% might have HSV-1 related palsy.5, Efficacy of anti-viral therapy in herpetic facial nerve paralysisThis study analyzed the HSV-1NZV load to assess the efficacy of the anti-viral therapy in patients with herpetic facial nerve paralysis. Anti-viral therapy may not be effective in all patients with HSV-1NZV reactivation because the facial paralysis can occur at various times between the early and the regression phase of HSV-1/VZV reactivation.6, Assessments of the botulinum toxin therapy for synkinesis after facial palsyWe have treated 17 patients with facial synkinesis after herpetic facial palsy with injection of botulinum toxin type A. The results indicate that the botulinum toxin injection is a safe and useful therapy for synkinesis after peripheral facial palsy. Less

1、面神经麻痹患者疱疹病毒再激活模式分析面瘫患者HSV-1NZV载量与面瘫发病的关系。结果表明，在HSV-1NZV重新激活的早期和消退期之间，面瘫可以发生在不同的时间段，提示疱疹病毒重新激活引起的面神经功能障碍和神经炎的进展存在不同的发展模式。2、利用DNA芯片分析贝尔麻痹患者的基因表达谱。我们发现了几个在Bell面瘫发病时表达上调或下调的基因。3、Bell面瘫患者的分析本研究分析了临床诊断的Bell面瘫患者面部运动恢复不完全的原因。结果表明，疱疹病毒或单纯疱疹病毒1型病毒再激活是导致…预后不良的主要原因我们分析了急性周围性面瘫患者HSV-1重新激活的发生率。结果提示，在临床诊断为Bell‘s面瘫的患者中，20%为ZSH，20%为非HSVNZV相关性面瘫，其余60%可能为HSV-1相关性面瘫。5、疱疹病毒性面神经麻痹的抗病毒治疗效果本研究通过分析HSV-1NZV载量来评价抗病毒治疗对疱疹病面神经麻痹患者的疗效。抗病毒治疗可能并不适用于所有HSV-1NZV重新激活的患者，因为面瘫可以发生在HSV-1/VZV重新激活的早期和消退期之间的不同时间。6、肉毒毒素治疗面瘫后突触的评估我们已经用A型肉毒毒素注射治疗了17例疱疹带状疱疹后面神经麻痹后的面瘫患者。结果表明，肉毒毒素注射是一种安全有效的治疗周围性面瘫后突触的方法。较少