Investigation on the pathogenesis of herpetic facial nerve paralysis

1、疱疹病毒在面神经麻痹中的再激活模式我们分析了面神经麻痹患者HSV-1 NZV载量与面神经麻痹发病的关系。结果表明，面神经麻痹可发生在HSV-1 NZV再激活的早期和消退期之间的不同时间，提示疱疹病毒再激活和神经炎的进展导致面神经功能障碍的发展存在不同的模式。2、Bell麻痹患者的基因表达分析使用DNA微阵列分析Bell麻痹患者的基因表达谱。我们发现了几个在贝尔麻痹发病时表达上调或下调的基因。3、贝尔麻痹患者面部运动功能恢复不完全的分析本研究分析了临床诊断贝尔麻痹患者面部运动功能恢复不完全的原因。结果提示VZV或HSV-1再激活是Bell麻痹的主要原因，预后差 ...更多信息 4、急性周围性面神经麻痹患者HSV-1再激活的发生率我们分析了急性周围性面神经麻痹患者HSV-1再激活的发生率。结果表明，在临床诊断的贝尔麻痹20%有HSV-NZV和20%有非HSV-NZV麻痹，其余60%可能有HSV-1相关麻痹。5，抗病毒治疗疱疹性面神经麻痹的疗效本研究分析了HSV-1 NZV载量，以评估抗病毒治疗疱疹性面神经麻痹患者的疗效。抗病毒治疗可能不是对所有HSV-1/NZV再激活的患者有效，因为面瘫可能发生在HSV-1/VZV再激活的早期和消退期之间的不同时间。6、肉毒杆菌毒素治疗面瘫后面部联动的评估我们通过注射A型肉毒杆菌毒素治疗了17例疱疹性面瘫后面部联动的患者。结果提示肉毒毒素注射治疗周围性面瘫后的联带运动是一种安全有效的治疗方法。少

1,Patterns of herpes virus reactivation in facial nerve paralysisWe analyzed the relationship between HSV-1NZV load and onset of facial paralysis in patients with facial paralysis. The results indicate that facial paralysis can occur at various times between the early and the regression phase of HSV-1NZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by herpes virus reactivation and the progression of neuritis.2,Gene expression analysis in patients with Bell's palsyGene expression profile was analyzed in patients with Bell's palsy using DNA microarray. We found several genes which were up-or down-regulated at the onset of Bell's palsy.3,Analysis of patients with Bell's palsy who showed incomplete recoveryThis study analyzed the causes of clinically diagnosed Bell's palsy who showed incomplete recovery of facial movement. The results indicate that VZV or HSV-1 reactivation is the major cause of Bell's palsy with poor prognosis … More .4, Prevalence of HSV-1 reactivation in acute peripheral facial paralysisWe analyzed the prevalence of HSV-1 reactivation in acute facial paralysis. The results suggested that in clinically diagnosed Bell's palsy 20% have ZSH and 20% have non-HSVNZV palsy, and the remaining 60% might have HSV-1 related palsy.5, Efficacy of anti-viral therapy in herpetic facial nerve paralysisThis study analyzed the HSV-1NZV load to assess the efficacy of the anti-viral therapy in patients with herpetic facial nerve paralysis. Anti-viral therapy may not be effective in all patients with HSV-1NZV reactivation because the facial paralysis can occur at various times between the early and the regression phase of HSV-1/VZV reactivation.6, Assessments of the botulinum toxin therapy for synkinesis after facial palsyWe have treated 17 patients with facial synkinesis after herpetic facial palsy with injection of botulinum toxin type A. The results indicate that the botulinum toxin injection is a safe and useful therapy for synkinesis after peripheral facial palsy. Less