Investigation on the pathogenesis of herpetic facial nerve paralysis

1、面神经麻痹患者疱疹病毒再激活模式分析面神经麻痹患者HSV-1NZV载量与面神经麻痹发病的关系。结果表明，在HSV-1NZV再激活的早期和退行期之间，面神经麻痹可以在不同的时间发生，提示疱疹病毒再激活引起的面神经功能障碍的发展和神经炎的进展存在不同的模式。2、贝尔氏麻痹患者基因表达分析应用DNA芯片分析贝尔氏麻痹患者基因表达谱。我们发现有几个基因在贝尔氏麻痹发病时被上调或下调。3、不完全恢复贝尔麻痹患者的分析本研究分析了临床上诊断为面部运动不完全恢复的贝尔麻痹患者的原因。结果表明，VZV或HSV-1的再激活是贝尔麻痹预后不良的主要原因。我们分析了急性周围性面瘫患者中HSV-1再激活的患病率。结果提示，临床上诊断的贝尔麻痹患者中，20%为ZSH， 20%为非hsvnzv麻痹，其余60%可能为HSV-1相关麻痹。5、疱疹性面神经麻痹的抗病毒治疗效果本研究分析了疱疹性面神经麻痹患者的HSV-1NZV载量，以评估抗病毒治疗的疗效。抗病毒治疗可能不是对所有HSV-1NZV再激活的患者都有效，因为面瘫可以在HSV-1/VZV再激活的早期和消退阶段之间的不同时间发生。6、肉毒毒素治疗面神经麻痹后面神经联动性的疗效评价我们用a型肉毒毒素注射治疗17例疱疹性面神经麻痹后面神经联动性，结果表明肉毒毒素注射治疗周围性面神经麻痹后面神经联动性是一种安全有效的治疗方法。少

1,Patterns of herpes virus reactivation in facial nerve paralysisWe analyzed the relationship between HSV-1NZV load and onset of facial paralysis in patients with facial paralysis. The results indicate that facial paralysis can occur at various times between the early and the regression phase of HSV-1NZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by herpes virus reactivation and the progression of neuritis.2,Gene expression analysis in patients with Bell's palsyGene expression profile was analyzed in patients with Bell's palsy using DNA microarray. We found several genes which were up-or down-regulated at the onset of Bell's palsy.3,Analysis of patients with Bell's palsy who showed incomplete recoveryThis study analyzed the causes of clinically diagnosed Bell's palsy who showed incomplete recovery of facial movement. The results indicate that VZV or HSV-1 reactivation is the major cause of Bell's palsy with poor prognosis … More .4, Prevalence of HSV-1 reactivation in acute peripheral facial paralysisWe analyzed the prevalence of HSV-1 reactivation in acute facial paralysis. The results suggested that in clinically diagnosed Bell's palsy 20% have ZSH and 20% have non-HSVNZV palsy, and the remaining 60% might have HSV-1 related palsy.5, Efficacy of anti-viral therapy in herpetic facial nerve paralysisThis study analyzed the HSV-1NZV load to assess the efficacy of the anti-viral therapy in patients with herpetic facial nerve paralysis. Anti-viral therapy may not be effective in all patients with HSV-1NZV reactivation because the facial paralysis can occur at various times between the early and the regression phase of HSV-1/VZV reactivation.6, Assessments of the botulinum toxin therapy for synkinesis after facial palsyWe have treated 17 patients with facial synkinesis after herpetic facial palsy with injection of botulinum toxin type A. The results indicate that the botulinum toxin injection is a safe and useful therapy for synkinesis after peripheral facial palsy. Less