Endoscopic tracheal balloon occlusion in congenital diaphragmatic hernia sheep model

内镜下气管球囊封堵术治疗羊先天性膈疝模型

• 批准号: 14571707
• 负责人: KOSHINAGA Tsugumichi
• 金额: $ 1.79万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571707/
• 关键词: congenital diaphragmatic hernia; pregnant sheep; pregnant guinea pig; pregnant rat; endoscopic tracheal occlusion

Aim : We aimed to produce animal model with left congenital diaphragmatic hernia and performed endoscopic tracheal occlusion treatment. We also discussed the clinical application for human fetal treatment in Japan.Methods : 1.Left diaphragmatic hernia production 2.Endotracheal occlusion by detachable balloonResults :1. Basic operative technique for diaphragmatic hernia in small animal. Guinea pigs at 40 days of gestation were used for left diaphragmatic hernia production. Also rats were used as a liver herniation model produced by nitrofen.2 Endoscopic apparatus. We performed endoscopic tracheal occlusion by detachable balloon on three sheep at 90days of gestation. One fetus of three died intrauterine due to premature detachment of the placenta. The rest underwent successfully Caesarean section.3. Left diaphragmatic hernia production in sheep. We produced surgically left diaphragmatic hernia in sheep at 75 days of gestation.4. A randomized trial of human fetal endoscopic tracheal occlusion performed by Harrison MR. et al. at UCSF. Eight of 11fetuses (73 percent) in the tracheal-occlusion group and 10 of 13 (77 percent) in the group that received standard care survived to 90 days of age (P=1.00). The tracheal occlusion did not improve survive or morbidity rates in he cohort of fetuses with congenital diaphragmatic hernia.These results do not give any supporting evidences to apply this treatment for human fetuses with congenital diaphragmatic hernia also in Japan. Severe congenital diaphragmatic hernias of Lung to head ratio (LHR) less than 0.9 must be a future issue to solve.

目的：建立左侧先天性膈疝动物模型，并进行内镜下气管闭塞治疗。我们还讨论了日本人胎治疗的临床应用。方法：1；左侧膈疝产生2。可拆卸球囊封堵气管。小动物膈疝的基本手术技术。用妊娠40天的豚鼠制作左膈疝。并以大鼠作为硝芬所致肝疝模型内窥镜设备。我们用可拆卸球囊对三只妊娠90天的绵羊进行了内窥镜气管闭塞术。三个胎儿中有一个因胎盘过早脱离而死于宫内。其余的都成功地接受了剖腹产手术。绵羊左侧膈疝的产生。我们在妊娠75天的绵羊中手术制造了左侧膈疝。一项由Harrison先生等人在UCSF进行的人胎儿内窥镜气管闭塞的随机试验。气管闭塞组的11个胎儿中有8个（73%）存活到90天，接受标准护理组的13个胎儿中有10个（77%）存活到90天（P=1.00）。气管闭塞不能提高先天性膈疝胎儿的生存率或发病率。这些结果没有提供任何支持的证据，适用于先天性膈疝的人胎儿的治疗也在日本。严重先天性膈疝肺头比（LHR）小于0.9必须是未来解决的问题。

项目成果

分娩に際しての諸問題とその解決 分娩誘発、前期破水、分娩遷延 分娩管理-よりよいお産のために-研修ノート

分娩过程中的问题及解决方法 引产、胎膜早破、延迟分娩 分娩管理 - 为了更好的分娩 - 培训笔记

• 发表时间: 2003
• 作者: Takagi K;Takagi K;Kazuya Matsumoto;Takagi K.;Matsumoto K;高木健次郎;Kazuya Matsumoto;高木健次郎;Ichiro Hashimoto;高木健次郎;高木健次郎;Ichiro Hashimoto;橋本一郎;高木健次郎;Hashimoto I;Takagi K;Hashimoto I;Ichiro Hashimoto;Takagi K.;Ichiro Hashimoto;高木健次郎;Hashimoto I;高木健次郎
• 通讯作者: 高木健次郎

Spontaneous localized intestinal perforation and intestinal dilatation in very-low-birthweight infants

• DOI: 10.1080/08035250600617123
• 发表时间: 2006-11-01
• 期刊: ACTA PAEDIATRICA
• 影响因子: 3.8
• 作者: Koshinaga, Tsugumichi;Gotoh, Hiroshi;Tomita, Ryouichi
• 通讯作者: Tomita, Ryouichi

Semiquantitative assessment of myelination using magnetic resonance imaging in normal fetal brains

• DOI: 10.1002/pd.873
• 发表时间: 2004-05-01
• 期刊: PRENATAL DIAGNOSIS
• 影响因子: 3
• 作者: Abe, S;Takagi, K;Kato, T
• 通讯作者: Kato, T

早産原因に関連する病態とその管理 妊娠中毒症

与早产原因相关的病理状况及其治疗 先兆子痫

• 发表时间: 2003
• 期刊: 産科と婦人科 70(12)
• 作者: Takagi K;Takagi K;Kazuya Matsumoto;Takagi K.;Matsumoto K;高木健次郎;Kazuya Matsumoto;高木健次郎
• 通讯作者: 高木健次郎

欧米における妊娠中毒症の考え方

欧美如何看待先兆子痫

• 发表时间: 2003
• 期刊: 周産期医学 33(10)
• 作者: Takagi K;Takagi K;Kazuya Matsumoto;Takagi K.;Matsumoto K;高木健次郎;Kazuya Matsumoto;高木健次郎;Ichiro Hashimoto;高木健次郎
• 通讯作者: 高木健次郎