Dental Application and Setting Mechanism of Calcium Phosphate Cement Made with Poly (malic acid)

聚苹果酸磷酸钙骨水泥的牙科应用及凝固机理

• 批准号: 14571860
• 负责人: HIBINO Yasushi
• 金额: $ 1.98万
• 依托单位: Meikai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571860/
• 关键词: Calcium phosphate; Poly (malic acid); Mechanical properties; Setting reaction; Cytotoxicity; FT-IR; X線回折; 崩壊率

The objective of this research was to investigate dental application for calcium phosphate cement made with poly (malic acid). The cement powder was used for ex-TCP and aqueous solutions of poly (malic acid) obtained by thermal polycondensation in four different concentrations (10, 20, 30, and 40 wt%) were used as the cement liquid at a mixing ratio of P/D= 1.0/1.0 or 1.5/1.0. The setting time, compressive strengths, and solubility/disintegration of the cements were determined. After compressive strength testing, the specimens were ground and subjected to powder x-ray diffractometry. The disc-shaped specimens were examined using SEM after the solubility and disintegration testing. Calcium phosphate cement with workable handling characteristics could be made when 30 and 40% poly (malic acid) were used as the cement liquid. An increase in the concentrations of poly (malic acid) in the cement liquid significantly shortened the setting time at 37℃ (p<0.05). An increase in the concentration … More s of poly (malic acid) in the cement liquid significantly increased the compressive strength (p<:0.05). The cement made with poly (malic acid) showed significantly greater amount of solubility and disintegration compared to malic acid (p<0.05). No noticeable peaks for hydroxyapatite and other reaction products were observed in any of the set cement specimens. The current study showed that could be made by mixing poly (malic acid) and α-TCP powder. The setting mechanism of a calcium phosphate cement made with poly (malic acid) is hypothesized as follows : when α-TCP powder is mixed with an aqueous solution of carboxylic acid, α-TCP decomposes, and Ca ions are released due to the high acidity of the solution. The released Ca ions are bound to the carboxyl groups by a chelate reaction. This may be the dominant reaction during the setting process. The experimental calcium phosphate cements in the present study cannot be used in clinical practice at this moment. Further materials characterization and exploration of this calcium phosphate cement is necessary. Less

本研究的目的是探讨聚苹果酸磷酸钙骨水泥的牙科应用。将水泥粉末用于ex-TCP，并且将通过热缩聚获得的四种不同浓度（10、20、30和40重量%）的聚（苹果酸）水溶液以P/D= 1.0/1.0或1.5/1.0的混合比用作水泥液体。测定了骨水泥的凝固时间、抗压强度和溶解度/崩解度。在压缩强度测试之后，将试样研磨并进行粉末X射线衍射。在溶解度和崩解试验后，使用SEM检查盘形试样。当使用30和40%聚苹果酸作为骨水泥液时，可以制备具有可操作性的处理特性的磷酸钙骨水泥。水泥液中聚苹果酸浓度的增加显著缩短了37℃下的凝固时间（p<0.05）。浓度增加 ...更多信息 骨水泥液中聚苹果酸的加入显著提高了抗压强度（P<0.05）。与苹果酸相比，用聚（苹果酸）制成的粘固剂显示出显著更大的溶解量和崩解量（p<0.05）。在任何凝固的骨水泥样本中均未观察到羟基磷灰石和其他反应产物的明显峰。研究表明，聚苹果酸与α-TCP粉末混合可制得α-TCP纳米复合材料。用聚苹果酸制成的磷酸钙骨水泥的固化机理假设如下：当α-TCP粉末与羧酸水溶液混合时，α-TCP分解，由于溶液的高酸性而释放出Ca离子。释放的Ca离子通过螯合反应与羧基结合。这可能是凝固过程中的主要反应。本研究中的实验性磷酸钙骨水泥目前不能用于临床实践。有必要对这种磷酸钙骨水泥进行进一步的材料表征和探索。少