EFFECTS OF REDUCTION OF BLOOD OXIDATION-REDUCTION POTENTIAL ON SURGICAL STRESS DURING SURGERY

手术期间血液氧化还原电位降低对手术应激的影响

• 批准号: 14571932
• 负责人: TANIGUCHI Shogo
• 金额: $ 1.79万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571932/
• 关键词: OXIDATION-REDUCTION POTENTIAL; OXIDATIVE STRESS; SURGERY; ELECTROLYTE SOLUTION; ASCORBIC ACID; ALKALI ION SOLUTION; 生体侵襲; 血中乳酸値; BE; 酸素ストレス; 還元剤

In this study we investigated the effectiveness of reduction of blood Oxidation- Reduction potential(ORP) on the oxidative stress during surgery. ORP of the various electrolyte solutions were measured, and all electrolyte solution showed lower ORP by addition of alkali ion solution and ascorbic acid. Addition of alkali ion solution and ascorbic acid for the blood samples showed same results. We also measured blood ORP of the patient during surgery and in severe shock state, and they elevated statistically in severe shock state.From these results we administered electrolyte solutions, such as lactated Ringer's solution, acetated Ringer's solution, and acetated Ringer's solution with 1% glucose, that have lower ORP. As a result, we could decrease blood ORP and lactate concentration, and improve acidosis of the patient with surgical stress.This result suggested that administration of more reduced solution would be useful for the patient with oxidative stress during surgery.

在本研究中，我们探讨了降低血液氧化还原电位（ORP）对手术中氧化应激的影响。测定了不同电解质溶液的ORP，碱离子溶液和抗坏血酸的加入使电解质溶液的ORP降低。加入碱离子溶液和抗坏血酸的血液样品显示相同的结果。我们还测量了患者在手术期间和严重休克状态下的血ORP，严重休克状态下ORP升高有统计学意义。根据这些结果，我们给予具有较低ORP的电解质溶液，如乳酸林格氏液、醋酸林格氏液和1%葡萄糖的醋酸林格氏液。结果可降低血ORP和乳酸浓度，改善手术应激患者的酸中毒。这一结果表明，给予更多的还原溶液将有助于患者在手术期间氧化应激。