Catalytic Hydroacylatlon using Rhodium Complex

在温和的反应条件下，水杨醛与1，4-五烯或1，5-己二烯在铑催化剂作用下发生分子间氢酰化反应，得到异氢酰化产物和正氢酰化产物。在氢酰化反应中，水杨醛和双烯对铑络合物的螯合作用起着至关重要的作用。异-和正-加氢酰化产物的比例可以通过添加水杨酸或胺来调节。各种铑配合物，溶剂和添加剂的影响进行了检查，并提出了合理的催化循环的机制的基础上的氘标记水杨醛实验的基础上。

Intermolecular hydroacylation between salicylaldehyde and 1,4-penta-or 1,5-hexadienes by Rh-catalyst proceeded under mild reaction conditions to give a mixture of iso-and normal-hydroacylated products. In the hydroacylation reaction, chelation of both salicylaldehyde and diene to the Rh-complex play a crucial role. The ratio of iso-and normal-hydroacylated products could be regulated by the addition of salicylic acid or amines. The effects of various Rh-complexes, solvents, and additives were examined, and the plausible mechanisms of the catalytic cycle were proposed on the basis of the basis of the deuterium-labeling salicylaldehyde experiments.