DEVELOPMENT OF NEW ASYMMETRIC REACTIONS BASED ON CONFORMATIONALY FIXED CYCLOALKANE-POLYOLS.

本研究在前人用酶法制备对映体纯环烷-1，2-二醇的研究基础上，开展了几个不对称反应的研究工作：1)以环烷-1，2-二醇为手性助剂，发展了一种新的不对称构筑季碳化合物的方法及其在螺环化合物合成中的应用；3)以手性环烷烃-1，2-二醇为手性源进行了不对称螺环化反应。

Based on our previous study for preparation of enantiomerically pure cycloalkane-1,2-diols by using enzymatic procedure, several asymmetric reactions have been developed in this research project.1)A new method for asymmetric construction of a quatemary carbon and its application to the synthesis of spiro-cyclic compound have been developed by using cycloalkane-1,2-diols as a chiral auxiliary.2)New types of asymmetric reactions have been developed by using "chiral enol ether" as a key intermediate : Two kinds of asymmetric Michael reaciton ; Asymmetric oxidation of beta-keto esters ; Chiral induction to meso-cyclic 1,2-diol.3)Asymmetric spiro-cyclization has been developed by using chiral cycloalkane-1,2-diol as a chiral sorce.