Macrocyclic Aromatic Hydrocarbons: Covalent-Template Synthesis and Host-Guest Chemistry with Synthetic Carbon Allotropes (A10#)

大环芳烃：共价模板合成和合成碳同素异形体的主客体化学 (A10

• 批准号: 470112261
• 金额: --
• 依托单位: Department Chemie und Pharmazie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/470112261?language=en
• 关键词: Macrocyclic; Aromatic; Hydrocarbons; Covalent; Template

The goal of A10 project is to develop two new families of macrocyclic PAHs, which can bind fullerenes, nanotubes, and biologically important guests. In a collaboration with project partners, we have designed a series of new supramolecular hosts, which are constructed from macrocyclic and curved PAHs bearing elementary binding sites (hydrogen bond donors, acceptors or charged groups). Charged and neutral hosts have a confined space ensuring their ability to bind various guest molecules in polar media. In work package WP-1 we will address the challenge how to convert curved PAHs into a macrocyclic structure with excellent solubility. We will study for the first time supramolecular SCA host-guest chemistry of new hosts with fullerenes and nanotubes in aqueous media. We expect to achieve a unique solubilisation activity of new macrocycles towards fullerenes and related guests that will give rise to new Inter-SCA-architectures in polar solutions. In WP-2 we propose to develop a covalent-template approach for the efficient synthesis of macrocyclic PAHs. This approach will deliver not only a new generation of supramolecular hosts containing curved PAHs, but also allow to prepare functionalized macrocyclic PAHs by the detachment of a template. The host-guest chemistry of the new systems with charged and neutral guests will be explored in both organic and aqueous solutions.

A10项目的目标是开发两个新的大环多环芳烃家族，它们可以结合富勒烯，纳米管和生物学上重要的客人。在与项目合作伙伴的合作中，我们设计了一系列新的超分子主体，这些主体由具有基本结合位点（氢键供体，受体或带电基团）的大环和弯曲的多环芳烃构建。带电和中性主体具有有限的空间，确保它们能够在极性介质中结合各种客体分子。在工作包WP-1中，我们将解决如何将弯曲的多环芳烃转化为具有优异溶解性的大环结构的挑战。我们将首次在水介质中研究具有富勒烯和纳米管的新主体的超分子SCA主客体化学。我们期望实现新的大环对富勒烯和相关客人的独特增溶活性，这将在极性溶液中产生新的SCA间结构。在WP-2中，我们提出了一个共价模板法的大环多环芳烃的有效合成。这种方法不仅提供了新一代的超分子主体含有弯曲的多环芳烃，但也允许制备功能化的大环多环芳烃的模板分离。新系统的主客体化学与带电和中性客人将在有机和水溶液中进行探索。