Macrocyclic Aromatic Hydrocarbons: Covalent-Template Synthesis and Host-Guest Chemistry with Synthetic Carbon Allotropes (A10#)

大环芳烃：共价模板合成和合成碳同素异形体的主客体化学 (A10

• 批准号: 470112261
• 金额: --
• 依托单位: Department Chemie und Pharmazie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/470112261?language=en
• 关键词: Macrocyclic; Aromatic; Hydrocarbons; Covalent; Template

The goal of A10 project is to develop two new families of macrocyclic PAHs, which can bind fullerenes, nanotubes, and biologically important guests. In a collaboration with project partners, we have designed a series of new supramolecular hosts, which are constructed from macrocyclic and curved PAHs bearing elementary binding sites (hydrogen bond donors, acceptors or charged groups). Charged and neutral hosts have a confined space ensuring their ability to bind various guest molecules in polar media. In work package WP-1 we will address the challenge how to convert curved PAHs into a macrocyclic structure with excellent solubility. We will study for the first time supramolecular SCA host-guest chemistry of new hosts with fullerenes and nanotubes in aqueous media. We expect to achieve a unique solubilisation activity of new macrocycles towards fullerenes and related guests that will give rise to new Inter-SCA-architectures in polar solutions. In WP-2 we propose to develop a covalent-template approach for the efficient synthesis of macrocyclic PAHs. This approach will deliver not only a new generation of supramolecular hosts containing curved PAHs, but also allow to prepare functionalized macrocyclic PAHs by the detachment of a template. The host-guest chemistry of the new systems with charged and neutral guests will be explored in both organic and aqueous solutions.

A10项目的目的是开发两个新的大环PAH家族，它们可以绑定富勒烯，纳米管和生物学上重要的客人。在与Project Partners的合作中，我们设计了一系列新的超分子宿主，这些宿主由具有基本结合位点（氢键供体，受体或带电组）的大环和弯曲的PAH构建。带电和中性的宿主具有狭窄的空间，可确保其在极地培养基中绑定各种客体分子的能力。在工作包WP-1中，我们将应对如何将弯曲的PAH转换为具有出色溶解度的大环结构的挑战。我们将首次研究新宿主的超分子SCA宿主 - 宿主化学，并在水性培养基中使用富勒烯和纳米管进行研究。我们希望将新的大环对富勒烯和相关客人进行独特的溶解活性，从而在极性溶液中产生新的SCA-CA-Architectures。在WP-2中，我们建议开发一种共价模板方法，以有效合成大环PAH。这种方法不仅将提供新一代的超分子宿主，其中包含弯曲的PAH，还可以通过模板的脱离来制备功能化的大环PAH。有机和水溶液中，将探索新系统的宿主 - 乐器化学。