Development and Application of Estimation at Bone Density of Children by Quantitative Ultrasound

定量超声估算儿童骨密度的开发与应用

• 批准号: 14580030
• 负责人: MIMURA Kan-ichi
• 金额: $ 1.92万
• 依托单位: Osaka Kyoiku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14580030/
• 关键词: children; Quantitative Ultrasound device for children; bone density; physical fitness; nutrition; fracture experience; 学童; 小児用超音波測定装置; レントゲン; 超音波骨密度測定装置CM-100; 踵骨測定位置; 足長; CM-100; AOS-100; UBIS3000

The purpose of this study was to develop a safer and more effective device named Quantitative Ultrasound (QUS) instrument, which will be specialized in assessing the bone density of children. In 2002, an adapter-A (F) capable to adjust the heel position in proportion to the foot length between heel and toe was developed, and the bone density of 189 children graded 1 to 6 were simultaneously assessed by QUS CM-100 (Furuno Electric, Co., Ltd.) together with the adapter, AOS-100 (Aloka, Co., Ltd.) and UBIS3000 (DMS, Co., Ltd.). We compared the obtained data from the above instruments and confirmed that QUS CM-100 adapter-A is the most reliable one. In 2003, after the calcaneus measurement position was concurrently investigated by X-ray examination and QUS CM-100 assessment on 41 grade 1〜6 pupils, we found that the accurate data could be obtained if 8 measurement boards in proportion to the foot length of primary school children were applied with 14mm ultrasonic beam together. In 2004, the bone density assessment on 3867 children aged from 6〜11 years old, as well as a questionnaire investigation about nutrition and exercise custom, were performed using the new developed QUS CM-100. As the results, even though a fall was observed on the 8-year-old boys and 9-year-old girls, there appeared almost no any change on the bone density. The 10-year-old children showed an increasing tendency, and the girls valued higher than the boys. In addition, the questionnaire indicated that the bone density positively correlated to exercise custom, but it correlated to neither nutrition nor fracture experience. Furthermore, we also assessed the bone density on 6216 children aged from 13 to 20 years old using the same instrument, and clarified the age-associated change in bone density aged between 6〜20 years old, as well as the relations among exercise, nutrition custom and fracture experience.

这项研究的目的是开发一种更安全、更有效的设备，名为定量超声(QUS)仪器，将专门用于评估儿童的骨密度。2002年，开发了一种能够按脚跟和脚趾之间的足长比例调整脚跟位置的适配器-A(F)，并用Quus CM-100(Furuno Electric，Co.，Ltd.)同时测量了189名1-6年级儿童的骨密度。连同适配器AOS-100(ALOKA，Co.，Ltd.)和UBIS3000(DMS，Co.，Ltd.)。我们比较了以上仪器的数据，确认QUS CM-100适配器-A是最可靠的。2003年，对41名1~6年级小学生的跟骨测量位置同时进行了X线片检查和QUS CM-100评定，发现用14 mm的超声束将8块与小学生足长成比例的测量板放在一起，即可获得准确的测量数据。2004年，采用新研制的QUS CM-100对3867名6~11岁儿童进行了骨密度测定，并进行了有关营养和运动习惯的问卷调查。结果是，尽管观察到8岁的男孩和9岁的女孩的骨密度有所下降，但骨密度几乎没有任何变化。10岁儿童的价值观呈上升趋势，女生的价值观高于男生。此外，调查问卷显示，骨密度与运动习惯呈正相关，与营养、骨折经历无关。此外，我们还使用同一仪器对6216名13~20岁的儿童进行了骨密度测量，明确了6~20岁儿童骨密度的年龄相关性变化，以及运动、营养习惯和骨折经历之间的关系。

项目成果

Gender- and Aged-Related Changes of Quantitative Ultrasound Measurement in the Japanese Young People Population

日本年轻人中定量超声测量的性别和年龄相关变化

• 发表时间: 2004
• 期刊: Osteoporosis Japan 12(4)
• 作者: Kan-ichi Mimura;Munehiro Tetsuguchi;Takehisa Yamamoto;Kiyoshi Nakatsuka;Kousei Yoh;Hiroya Morii;Tatsuo Arai
• 通讯作者: Tatsuo Arai