Interaction of mineral intake and vitamin D receptor polymorphism on bone mineral density of women

点击翻译按钮获取中文摘要

The purpose of this study was to clarify associations between environmental factors, genetic factors, and their possible interaction v s.bone mineral density (BMD) of young women. Apa 1 and Taq 1 polymorphisms of vitamin D receptor were analyzed by restriction fragment length polymorphism (RFLP) method. Bone mineral density at the lumbar spine and hip was measured by dual-energy X-ray absorptiometry. Lifestyles were assessed by interview. 1)BMD was cross-sectionally associated with body weight, grip strength, and serum intact parathyroid hormone concentrations. 2)BMD was predicted by weight gain in infancy and the prepubertal period. 3)Subjects with an "AA" genotype had greater decrease in BMD at the femoral neck than those with an "Aa" or "aa" genotype. However, no interactions between environmental factors v.s.vitamin D polymorphisms on BMD were found.