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Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism in Postmenopausal Japanese Women.

异黄酮和运动对绝经后日本女性骨和脂质代谢的协同作用。

基本信息

批准号：
16500536
负责人：
ISHIMI Yoshiko
金额：
$ 2.05万
依托单位：
National Institute of Health and Nutrition
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Introduction : The additive effects of isoflavones and exercise on bone and lipid metabolism have been demonstrated in estrogen-deficient animals. In this study, we determined the effects of isoflavone intake, walking exercise, and their interaction on bone, fat mass, and lipid metabolism over 1 year in postmenopausal Japanese women.Methods : A total of 136 postmenopausal women at <5 years after the onset of menopause were randomly assigned to four groups : (1) placebo, (2) walking (45 min/day, 3 days/week) with placebo, (3) isoflavone intake (75 mg of isoflavone conjugates/day), and (4) combination of isoflavone plus walking. Bone mineral density (BMD), fat mass, serum lipid, and serum and urinary isoflavone concentrations were assessed.Results : A significant main effect of isoflavone on the reduction in trunk fat mass was obtained at 12 months. Significant main effects of walking on the reduction in fat mass in the whole body and the trunk were observed at 3, 6, and 12 months and th … More at in the legs and arms at 6 and 12 months. Serum HDL cholesterol concentration significantly increased by 12 months following the walking and the combined intervention. After 12 months, a significant main effect of isoflavone on BMD was observed only at Ward's triangle. Walking prevented bone loss at the total hip and the Ward's triangle to significant degrees. The effect of the combined intervention on BMD and fat mass was greater than that of either alone. No significant interaction was observed between isoflavone and walking in any measurements recorded during the study.Conclusion : Our study suggest that combined intervention of 75 mg/day of isoflavone intake and walking exercise 3 times/week for 1 year showed a trend for a greater effect on BMD at total hip and Ward's triangle regions than either alone. Intervention with isoflavone in postmenopausal Japanese women showed a modest effect on BMD when compared with those in the Westerners. Further studies over longer treatment duration that include assessment of BMD at various regions are necessary to ascertain the clinical significance of the combined intervention of isoflavone plus walking in postmenopausal women. Less

前言：在雌激素缺乏的动物中，异黄酮类和运动对骨和脂代谢的相加作用已被证明。方法：将136名绝经后妇女随机分为4组：(1)安慰剂组；(2)安慰剂组；(2)安慰剂+步行组；(3)异黄酮组(75 mg/d)；(4)异黄酮加步行组。测定两组大鼠的骨密度、脂肪量、血脂、血、尿异黄酮值。结果：12个月龄时，异黄酮组对躯干脂肪量的降低具有显著的主效应。在3个月、6个月和12个月时，观察到步行对全身和躯干脂肪质量的减少有显著的主效应，…在6个月和12个月时，腿和手臂上的脂肪含量更高。步行和联合干预后12个月，血清高密度脂蛋白胆固醇浓度显著升高。12个月后，异黄酮组仅在Ward‘s三角区观察到显著的主效应。步行在很大程度上防止了全髋关节和Ward‘s三角的骨质流失。联合干预对骨密度和脂肪量的影响大于单独干预。在研究期间的任何测量中，没有观察到异黄酮与步行之间的显著交互作用。结论：我们的研究表明，在为期一年的时间里，每天摄入75 mg异黄酮加每周3次步行锻炼的联合干预对全髋部和Ward三角区的BMD的影响比单独使用任何一种方法都要大。与西方人相比，在绝经后的日本女性中，异黄酮类药物的干预对骨密度的影响不大。有必要在更长的疗程内进行进一步的研究，包括评估不同区域的骨密度，以确定异黄酮加步行联合干预对绝经后妇女的临床意义。较少

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High bone mass gained by exercise in growing mice is increased by subsequent reduced exercise.

生长中的小鼠通过运动获得的高骨量会随着随后运动量的减少而增加。

DOI：
发表时间：
2004
期刊：
J Appl Physiol 97・3
影响因子：
0
作者：
Wu J;Wang XX;Chiba H;Higuchi M;Yamada K;Ishimi Y.
通讯作者：
Ishimi Y.

Equol, a metabolite of daizdein, Inhibits bone loss in ovariectomized mice.

雌马酚是黄豆苷的代谢物，可抑制卵巢切除小鼠的骨质流失。

DOI：
发表时间：
2004
期刊：
J Nutr 134
影响因子：
0
作者：
Fujioka M;Uehara M;Wu J;Adlerereutz H;Yamada K;Ishimi Y.
通讯作者：
Ishimi Y.

High bone mass gained by excrcise in growing mice is increased by subsequent reduced exercise.

生长中的小鼠通过运动获得的高骨量会随着随后运动量的减少而增加。

DOI：
发表时间：
2004
期刊：
J Appl Physiol 97・3
影响因子：
0
作者：
Wu J;Wang XX;Chiba H;Higuchi M;Yamada K;Ishimi Y.
通讯作者：
Ishimi Y.

Equol, a metabolite of daizdein, Inhibits bone 1 in ovariectomized mice

雌马酚，大豆苷元的代谢物，抑制卵巢切除小鼠的骨 1

DOI：
发表时间：
2004
期刊：
J Nutr 134・10
影响因子：
0
作者：
Fujioka M;Uehara M;Wu J;Adlercreutz H;Yamada K;Ishimi Y.
通讯作者：
Ishimi Y.

Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausa1 Japanese Women : A One-year Randomized Placebo-controlled tria1

异黄酮和运动对绝经后日本女性骨矿物质密度和脂肪量的影响1：一项为期一年的随机安慰剂对照试验1

DOI：
发表时间：
2006
期刊：
J Bone Mineral Res 21・5
影响因子：
0
作者：
Wu J;0ka J;Tabata I;Higuchi M;Toda T;Fuku N;Ezaki J;Sugiyama F;Uchiyama S;Yamada Y;Ishimi Y.
通讯作者：
Ishimi Y.