Research for brain mechanism of visual and auditory memory in rats
大鼠视觉和听觉记忆的脑机制研究
基本信息
- 批准号:16530463
- 负责人:
- 金额:$ 0.9万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Studies have shown that rats have a greater short-term memory in response to auditory information over visual information (ex. Tsutsui, 1998). This phenomenon is known as the modality effect on memory. In this study, the relationship between the modality effect and cholinergic pathways was examined in rats brains. Eighteen rats were trained to perform a successive delayed matching-to-sample (SDMTS) task, using operant chambers with two retractable levers. Paired stimuli (S1-S2), which was divided by a delay interval of 1 second, 3 seconds, or 5 seconds, was presented to the animals. The four types of S1 and S2 combinations were as follows : Light-Light, Light-Tone, Tone-Tone, and Tone-Light. The rats had to press one of the two levers depending on the combination of the stimuli : When the modality of S1 was identical to that of S2, pressing the right lever was rewarded with a food pellet, and when the modality of S1 was different from that of S2, pressing the left lever was rewarded in the same manner. After the acquisition of the SDMTS, half of the rats were given a lesion into the nucleus basalis of Meynert (nbm) unilaterally, and the other half received a sham operation. Lesions given to the nbm disrupted the retention of auditory information, as a function of the length of the delay interval between S1 and S2. Rats whose nbm was destroyed were not able to retain visual information irrespective of the length of the delay interval. As a result, it has been suggested that the nbm has two different roles according to the modality of memory information. There is a possibility that the nbm is related to the short-term memory of auditory information and to the long-term memory of visual information.
研究表明,大鼠对听觉信息的短期记忆比视觉信息更强。Tsutsui,1998)。这种现象被称为记忆的通道效应。在这项研究中,在大鼠大脑中检查了通道效应与胆碱能通路之间的关系。18只大鼠进行训练,以执行连续延迟匹配到样品(SDMTS)的任务,使用操作室与两个可伸缩的杠杆。将配对刺激(S1-S2)除以1秒、3秒或5秒的延迟间隔,呈现给动物。S1和S2的四种组合如下:光-光、光-音、音-音和音-光。根据刺激的组合,大鼠必须按下两个杠杆中的一个:当S1的模态与S2的模态相同时,按下右杠杆会得到食物颗粒,当S1的模态与S2的模态不同时,按下左杠杆会以相同的方式得到奖励。在获得SDMTS后,一半的大鼠给予单侧Meynert基底核(nbm)的损伤,另一半接受假手术。对nbm的损伤破坏了听觉信息的保留,作为S1和S2之间延迟间隔长度的函数。无论延迟间隔的长度如何,nbm被破坏的大鼠都不能保留视觉信息。因此,根据记忆信息的形式,神经背调有两种不同的作用。有一种可能性是,nbm与听觉信息的短时记忆和视觉信息的长时记忆有关。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
集団茶園地帯における地下水水質と窒素・リン流出負荷量の推定
集体茶园区地下水水质及氮磷径流负荷估算
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:山本富久;中曽根英雄;松澤泰宏;黒田久雄;加藤亮
- 通讯作者:加藤亮
Development of a water quality tank model classified by land use for nitrogen load reduction scenarios
开发按土地利用分类的水质池模型,以减少氮负荷情景
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Satiraporn;S.;檜山哲哉;高橋厚裕;橋本 哲;福嶌義宏;Tasuku Kato
- 通讯作者:Tasuku Kato
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TSUTSUI Yuji其他文献
TSUTSUI Yuji的其他文献
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19530646 - 财政年份:2007
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$ 0.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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