Dopaminergic mechanisms and operant behavior in rats

在这项研究中，我们研究了动物的操作行为与中枢神经系统的多巴胺能神经传递之间的关系。伏隔核多巴胺传递的抑制延迟了反应的启动，使其难以获得新的学习任务。另一方面，纹状体DA传递的损害降低了当损害提供给D1受体时的反应速度，并降低了提供给D2受体的反应的准确性。这些结果表明，伏核和纹状体中的DA系统在动物操作行为的启动和控制中起重要作用。

In this research, we investigated the relationship between operant behavior in animals and the dopaminergic (DA) neurotransmission in the central nervous system. Inhibition of the DA transmission at the nucleus accumbens delayed the response initiation and made it difficult to acquire new learning tasks. On the other hand, impairment of the DA transmission in the striatum decreased the response speed when the impairment was provided to the D1 receptors, and decreased the accuracy of responses when the impairment was provided to the D2 receptors. These results suggested that the DA system in the nucleus accumbens and the striatum have an important role for the initiation and the control for operant behavior in animals.