Involvement of endogenous cannabinoids in the pharmacological effects of cannabinoids

内源性大麻素参与大麻素的药理作用

• 批准号: 16590096
• 负责人: WATANABE Kazuhito
• 金额: $ 2.3万
• 依托单位: Hokuriku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590096/
• 关键词: tetrahydrocannabinol; endogenous cannabinoid; anandamide; 2-arachidonoylglycerol; pharmacological effect; tolerance development; catalepsy; hypothermia; 体温下降作用

Pharmacological interaction in mice between cannabinoids and endogenous cannabinoids was studied and the following reaults were obtained.1)Tolerance developed in the cataleptogenic effect of anandamide but not in the hypothermic effect of the endogenous cannabinoid.1)A significant cross-tolerance was not developed in the cataleptogenic effect of tetrahvdrocannabinol and anandamide.1)A significant cross-tolerance was developed in the hypothermic effect of anandamide in tetrahydrocannabinol-tolerant mice, but not in mice pretreated with cannabidol and cannabinol1)Anandamide attenuated the hypothermic effects of tetrahydrocannabinol and its active metabolites, 11-hydroxy-tetrahvdrocannabinol and 11-oxo-tetrahydrocannabinol1)2-Arachidonoylglycerol also attenuated the hypothermic effect of 11-hydroxy-tetrahydrocannabinolThese results indicate that anandamide and 2-arachidonoylglycerol interact with certain cannabinoids in their pharmacological effects.

研究了大麻素和内源性大麻素之间小鼠的药理学相互作用并获得以下含量。1）1）在anandamide的催化作用效应中产生的耐受性，但在内源性大麻素的低温作用中并未在催化性andepant效应中产生重要的thealod and型thealepnab and型thealahvdrocant andablahvdrocant andabnabriol效应。在四氢大麻醇耐耐耐剂的小鼠中，芳族酰胺的低温作用，但没有在用大麻二醇和大麻醇1的小鼠中）anandamide衰减的小鼠减弱了四氢可诺酚及其活跃的活性代谢物的低体温效应11-氧化四氢大麻酚1）2-芳基二烯酰甘油还减轻了11-羟基四氢核酸酯的结果表明，anandamide和2-芳基二烯丙基甲酰甘油烯烃与某些大麻素相互作用。

项目成果

Identification and determination of cannabinoids in both commercially available and cannabis oils stored long term

市售油和长期储存的大麻油中大麻素的鉴定和测定

• 发表时间: 2005
• 期刊: J.Health Sci. 51
• 作者: Mamoru Yotoriyama;Eiji Ishiharajima;Yoko Kato;Akiko Nagato;Setsuko Sekita;Kazuhito Watanabe;Ikuo Yamamoto
• 通讯作者: Ikuo Yamamoto

Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation. of 7β-hydroxy-Δ^8-tetrahydrocannabmol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes

睾酮和黄体酮对猴肝微粒体中 7β-羟基-Δ^8-四氢大麻酚到 7-oxo-Δ^8-四氢大麻酚的 NADH 和 NADPH 依赖性氧化的刺激作用。

• 发表时间: 2005
• 期刊: Drug Metab. Pharmacokinet. 20・5
• 作者: A.Hanaki;J.Ueda;N.Ikota;Okamoto et al.;T.Funahashi et al.
• 通讯作者: T.Funahashi et al.

Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7β-hydroxy-D^8-tetrahydrocannabinol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes

睾酮和黄体酮对猴肝微粒体中 7β-羟基-D^8-四氢大麻酚 7-oxo-Δ^8-四氢大麻酚 NADH 和 NADPH 依赖性氧化的刺激作用

• 发表时间: 2005
• 期刊: Drug Metab.Pharmacokinet. 20
• 作者: Tatsuya Funahashi;Yuuki Tanaka;Satoshi Yamaori;Toshiyuki Kimura;Tamihide Matsunaga;Shigeru Ohmori;Takashi Kageyama;Ikuo Yamamoto;Kazuhito Watanabe
• 通讯作者: Kazuhito Watanabe

Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7β-hydroxy-Δ^8-tetrahydrocannabinol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes

睾酮和黄体酮对猴肝微粒体中 7β-羟基-Δ^8-四氢大麻酚 7-oxo-Δ^8-四氢大麻酚 NADH 和 NADPH 依赖性氧化的刺激作用

• 发表时间: 2005
• 期刊: Drug Metab.Pharmacokinet. 20・5
• 作者: T.Funahashi;Y.Tanaka;S.Yamaori;T.Kimura;T.Matsunaga;S.Ohmori;T.Kageyama;I.Yamamoto;K.Watanabe
• 通讯作者: K.Watanabe

In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes

大麻素对大鼠睾丸微粒体孕酮17α-羟化酶活性的体外抑制作用

• 发表时间: 2005
• 期刊: J.Health Sci. 51・3
• 作者: T.Funahashi;H.Ikeuchi;S.Yamaori;T.Kimura;I.Yamamoto;K.Watanabe
• 通讯作者: K.Watanabe