The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide

内源性大麻素Anandamide的免疫调节作用。大麻酰胺是一种天然存在的脂肪酸，作用于大脑和外周表达的大麻素受体。我们的研究小组提出了一项新的建议，通过提出anandamide系统是一个重要的免疫调节系统，可以被入侵的病原体靶向，从而挑战了疾病过程的传统模型。我们认为，细菌或病毒作用于受体，阻断免疫反应，破坏anandamide系统，导致慢性疾病状态。在这一点上，我们有充分的证据表明阿南达胺是免疫调节剂，然而，我们对其确切的生理作用知之甚少。这项研究的目的是开始描述阿南胺系统的免疫调节作用。该项目将提供对这一内源性控制系统的全面了解，其免疫学特性以前没有被描述过。这项研究的结果可能会导致确定新的途径，为开发药物干预措施，可以针对该系统。

The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide. Anandamides are naturally occurring fatty acids that act at the cannabinoid receptor expressed in the brain and periphery. A new proposal by our research group challenges traditional models of the disease process by suggesting that the anandamide system is an important imunoregulatory system that can be targeted by invading pathogens. We propose that disruption to the anandamide system, by bacteria or viruses acting at the receptor to block immunological responses, contributes to chronic illness states. At this point we have good evidence that anandamides are immunoregulators, however, we have very little knowledge of their precise physiological role. The aim of this research is to begin to characterise the immunoregulatory role of the anandamide system. This project will provide a comprehensive understanding of this endogenous control system, the immunological properties of which have not previously been described. The outcome of this research may lead to the identification of new avenues for the development of pharmaceutical interventions that can target this system.