Historical aspects and future of characteristics of early-onset type 2 diabetes in Japan

使用东京女子医科大学糖尿病中心（TWMU）30岁以前诊断的1型（n= 1，675）和2型（n= 2，259）糖尿病患者的数据库，这些日本患者自20世纪60年代以来首次就诊时就登记在该中心，我们进行了一项以医院为基础的研究，以阐明在过去40年中30岁以前发生的1型和2型糖尿病的临床特征的时程变化。根据以往日本儿童期发病的1型糖尿病报告，1型糖尿病患者中女性占优势。从1型和2型糖尿病患者的比例来看，2型糖尿病一直占优势。有肥胖史的2型糖尿病患者的数量随着时间的推移而增加，这表明他们被诊断为2型糖尿病的发病年龄可能随着时间的推移而降低。相比之下，1型糖尿病的发病年龄一直在随着时间的推移而增加。2型糖尿病患者的一级亲属的糖尿病家族史没有显著差异，无论是否有肥胖史。与相应的男性患者相比，在15岁之前诊断为2型糖尿病的女性患者的母亲患有糖尿病。

Using a database of patients with type 1 (n=1,675) and type 2 (n=2,259) diabetes diagnosed before the age at 30 years of the Diabetes Center, Tokyo Women's Medical University (TWMU), at which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study to clarify time-course changes in clinical features of type 1 and type 2 diabetes developing before the age of 30 years over the last 40 years. From previous reports of Japanese childhood-onset type 1 diabetes, there has been a female dominancy in patients with type 1 diabetes. From the ratio of patients with type 1 and type 2 diabetes, there has been a type 2 diabetes dominancy. The number of patients with type 2 diabetes with a past history of obesity increased with time, and it was suggested that the onset age at which they were diagnosed with type 2 diabetes may have been getting lower with time. In contrast, the onset age of type 1 diabetes has been increasing with time. There was no marked difference in family history of diabetes in the first-degree relatives of patients with type 2 diabetes, regardless of the presence or absence of a past history of obesity. More female patients with type 2 diabetes diagnosed before the age of 15 years had mothers with diabetes compared to corresponding male patients.