Historical aspects and future of characteristics of early-onset type 2 diabetes in Japan

日本早发2型糖尿病特征的历史回顾和未来

• 批准号: 16590563
• 负责人: UCHIGATA Yasuko
• 金额: $ 2.18万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590563/
• 关键词: early-onset type 1 diabetes; early-onset type 2 diabetes; past history of obesity; family history; mortality; 糖尿病; 糖尿病合併症; 大血管障害; 足病変; 生命予後; 糖尿病性合併症; 細小血管障害; 2型糖尿病; 若年発症糖尿病; BMI

Using a database of patients with type 1 (n=1,675) and type 2 (n=2,259) diabetes diagnosed before the age at 30 years of the Diabetes Center, Tokyo Women's Medical University (TWMU), at which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study to clarify time-course changes in clinical features of type 1 and type 2 diabetes developing before the age of 30 years over the last 40 years. From previous reports of Japanese childhood-onset type 1 diabetes, there has been a female dominancy in patients with type 1 diabetes. From the ratio of patients with type 1 and type 2 diabetes, there has been a type 2 diabetes dominancy. The number of patients with type 2 diabetes with a past history of obesity increased with time, and it was suggested that the onset age at which they were diagnosed with type 2 diabetes may have been getting lower with time. In contrast, the onset age of type 1 diabetes has been increasing with time. There was no marked difference in family history of diabetes in the first-degree relatives of patients with type 2 diabetes, regardless of the presence or absence of a past history of obesity. More female patients with type 2 diabetes diagnosed before the age of 15 years had mothers with diabetes compared to corresponding male patients.

使用东京女子医科大学糖尿病中心（TWMU）30岁以前诊断的1型（n= 1，675）和2型（n= 2，259）糖尿病患者的数据库，这些日本患者自20世纪60年代以来首次就诊时就登记在该中心，我们进行了一项以医院为基础的研究，以阐明在过去40年中30岁以前发生的1型和2型糖尿病的临床特征的时程变化。根据以往日本儿童期发病的1型糖尿病报告，1型糖尿病患者中女性占优势。从1型和2型糖尿病患者的比例来看，2型糖尿病一直占优势。有肥胖史的2型糖尿病患者的数量随着时间的推移而增加，这表明他们被诊断为2型糖尿病的发病年龄可能随着时间的推移而降低。相比之下，1型糖尿病的发病年龄一直在随着时间的推移而增加。2型糖尿病患者的一级亲属的糖尿病家族史没有显著差异，无论是否有肥胖史。与相应的男性患者相比，在15岁之前诊断为2型糖尿病的女性患者的母亲患有糖尿病。

项目成果

The proportion of diabetes type in Japanese early-onset diabetes

日本早发性糖尿病中糖尿病类型的比例

• 发表时间: 2007
• 期刊: Diabetes Care (in press)
• 作者: Ogawa Y;Uchigata Y et al.
• 通讯作者: Uchigata Y et al.

The proprtion of diabetes type in Japanese early-onset diabetes

日本早发性糖尿病中糖尿病类型的比例

• 发表时间: 2007
• 期刊: Diabetes Care (in press)
• 作者: Ogawa Y;Uchigata Y;et al.
• 通讯作者: et al.

糖尿病学

糖尿病学

• 发表时间: 2008
• 作者: 長谷川豊;片桐秀樹
• 通讯作者: 片桐秀樹

小児科時代に発症した2型糖尿病の初期教育のポイント

儿童期2型糖尿病早期教育要点

• 发表时间: 2005
• 期刊: 糖尿病診療マスター 3
• 作者: Ogawa Y;Uchigata Y et al.;Kotomi Tokuyama;今西二郎;内潟 安子;今西二郎;Yasuko Uchigata;今西二郎;内潟 安子;Imanishi J;Iwakiri D. et al.;内潟 安子
• 通讯作者: 内潟 安子

小児・思春期糖尿病

儿童/青少年糖尿病

• 发表时间: 2004
• 期刊: 糖尿病 47
• 作者: Ogawa Y;Uchigata Y et al.;Kotomi Tokuyama;今西二郎;内潟 安子;今西二郎;Yasuko Uchigata;今西二郎;内潟 安子;Imanishi J;Iwakiri D. et al.;内潟 安子;Imanishi J;内潟 安子
• 通讯作者: 内潟 安子