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T cell epitope of GAD antigen in type 1 diabetes

T cell epitope of GAD antigen in type 1 diabetes
1型糖尿病GAD抗原T细胞表位
批准号:
16590894
负责人:
SHIMADA Akira
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2005

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中文摘要
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英文摘要
Typical type 1 diabetic patients were recruited after obtaining informed consent and approval of ethics committee of Keio Univ. School of Medicine. Among those patients, 33 year old type 1 diabetic patient with GAD antibody, short duration of disease, and HLA DR9 was selected. Peripheral blood lymphocytes were obtained from the patient, and those were stimulated with recombinant human GAD antigen to establish GAD reactive T cell clones. We could obtain a T cell clone, and confirmed that the phenotype of the clone is CD4, and indeed the clone reacts specifically to GAD antigen. We are now stimulating the clone with GAD peptide to identify the T cell epitopes.
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GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
GAD反应性T细胞主要在携带HLA DR9的自身免疫相关1型糖尿病患者中检测到
DOI: --
发表时间: 2004
期刊: Ann N Y Acad Sci. 1037
影响因子: --
作者: [中崎満浩, 加計正文, Itoh A et al.]
通讯作者: Itoh A et al.
GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9.
GAD反应性T细胞主要在携带HLA DR9的自身免疫相关1型糖尿病患者中检测到。
DOI: --
发表时间:
期刊: Ann N Y Acad Sci. (In press)
影响因子: --
作者: [Arata Itoh, Akira Shimada]
通讯作者: Akira Shimada
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    15K03356
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  • 资助金额:
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  • 财政年份:
    2015
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    2011
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    2010
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    $2.16万
  • 财政年份:
    2010
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