Pathological evaluation for long-term renal graft survival-Comparison with regulatory T cells

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10-year protocol biopsies have been performed in sixteen patients treated with Calcineurin inhibitor(CNI) continuously. All kidney grafts were functioning well at the time of biopsy with the mean serum creatinine level of 1.6±0.8mg/dl. The specimen of biopsy showed various degrees of tissue injury. According to the Banff grading, allograft glomerulopathy(cg) was observed in one case. Interstitial fibrosis(ci) and tubular atrophy(ct) were observed more frequently in thirteen(81%) and fifteen(93%) cases, respectively. Fibrous intimal thickening(cv) was seen in one(7%) case. Arteriolar hyaline thickening(ah) was seen in fourteen(87%) cases. These findings were associated with chronic rejection in one case, recurrence of original disease in four(25%) cases, toxicity of CNI in fourteen (87%) cases. Longer follow up studies are needed to confirm whether CNI should be continued or not in long-term period following kidney transplantation for better graft survival.