The analysis of TLR and TCR Vβ repertoire which would determinate and innate immunity

白细胞中的巨噬细胞、树突状细胞、中性粒细胞、NK细胞和γδT细胞对细菌、病毒和异常细胞具有天然免疫作用。它们有针对每个抗原的受体，称为Toll样受体(TLR)。在人类系统中，TLR1~9的表达并不相同，这使得细胞在TLR与配体相遇时释放的细胞因子不同。这些TLR表达的差异将决定感染或癌症患者的临床进展。除细胞因子的释放外，TLR的信号转导还可激活MyD88和NF-kB基因，诱导细胞表面分子的表达，从而激活NK细胞或γδT细胞。各TCRVβ的群体间存在差异。然而，在这项研究中没有发现TLR表达与TCRVβ谱系之间的任何相关性。特别是TCRVβ谱在诱导所需免疫中起着重要作用，今后需要对肿瘤或感染患者的TLR表达和TCRVβ谱进行分析，以评估他们的免疫功能，为癌症和感染的治疗提供新的策略。

An innate immunity against bacteria, virus and abnormal cells is carried on the macrophage, dendritic cell, neutrophil, NK cell and γδT cell which belong to white blood cell. They have the receptor against each antigen named toll-like receptor (TLR). In human system, the expressions of TLR1~9 are not equal and that make the differences of cytokine release from the cells when their TLR meet the ligand. These differences of TLR expression would decide the clinical progress in the patients with infection or cancer. As well as the cytokine release, the signal transduction from TLR would activate MyD88 and NF-kB gene, and induce the expression of cell surface molecules which could activate the NK cells or γδT cells.The analysis of TCR Vβ repertoire was also done in the same patients. There were differences in the populations of each TCR Vβ. However, any correlation between TLR expression and TCR Vβ repertoire were not seen in this study. Especially, it was suggested that TCR Vβ repertoire would make an important role to induce a required immunity.From now on, the analysis of TLR expression and TCR Vβ repertoire in the patients of cancer or infection will be needed to assess their immunological function to develop a new strategy for cancer and infection.