Personalized analysis of an innate immune response by targeting Toll-like receptor signal pathway related gene

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Expressions of TLRs were examined by flowcytometory on human innate immune cells. CD14 positive cells expressed TLR4 and dendritic cells expressed TLR9 on their surfaces. There were several differences in the expressions of TLRs by individuals. The quantity of MyD88 and TRAF6 mRNA in the CD14 positive cells increased when the TLR ligands, BCG-CWS were added in the culture. These results demonstrated the mechanism of Type 1 cytokine secretion by TLR signal pathway.