The study for mechanism of signal transduction for metastasis and invasion of pancreatic cancer

我们对胰腺癌转移和侵袭的信号转导机制进行了研究。本研究以四株胰腺癌细胞为研究对象，报道了迄今为止的研究结果。1.四株胰腺癌细胞均表达c-jun mRNA和c-jun蛋白。2.4株胰腺癌细胞具有不同的激活蛋白-1(AP-1)活性。3.激活AP-1的MT-21呈剂量依赖性地抑制胰腺癌细胞的生长和侵袭能力。4.手术标本中AP-1蛋白的表达与胰腺癌细胞的侵袭能力和转移活性之间的关系未见报道，今后我们将进一步阐明AP-1与胰腺癌的关系。

We have studied for mechanism of signal transduction for metastasis and invasion of pancreatic cancer. We used four pancreatic cancer cell lines for our study.We report the results that we acquired till now as fellows.1.All four pancreatic cancer cell lines expressed c-jun mRNA and c-Jun protein.2.Four pancreatic cancer cell lines had different activities of activator protein-1(AP-1). We suggest that there is a connection between activation of activator protein-1 and hepatic metastasis of pancreatic cancer.3.MT-21 that activate AP-1 inhibited growth and invasive ability of pancreatic cancer cell lines in dose dependent.4.We did not show the relationship between the metastatic and invasive activity, and the expression of AP-1 protein on surgical specimens.In the future, we will try to make clear the relationship between pancreatic cancer and AP-1 furthermore.