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The study for mechanism of signal transduction for metastasis and invasion of pancreatic cancer

胰腺癌转移、侵袭的信号转导机制研究

基本信息

批准号：
16591336
负责人：
TAKEYAMA Hiromitsu
金额：
$ 2.24万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591336/
关键词：
AP-1 MT-21 Pancreatic cancer

项目摘要

We have studied for mechanism of signal transduction for metastasis and invasion of pancreatic cancer. We used four pancreatic cancer cell lines for our study.We report the results that we acquired till now as fellows.1.All four pancreatic cancer cell lines expressed c-jun mRNA and c-Jun protein.2.Four pancreatic cancer cell lines had different activities of activator protein-1(AP-1). We suggest that there is a connection between activation of activator protein-1 and hepatic metastasis of pancreatic cancer.3.MT-21 that activate AP-1 inhibited growth and invasive ability of pancreatic cancer cell lines in dose dependent.4.We did not show the relationship between the metastatic and invasive activity, and the expression of AP-1 protein on surgical specimens.In the future, we will try to make clear the relationship between pancreatic cancer and AP-1 furthermore.

本研究旨在探讨胰腺癌侵袭转移的信号转导机制。本研究以四种胰腺癌细胞系为研究对象，报告了我们迄今为止所获得的结果：1.四种胰腺癌细胞系均表达c-jun mRNA和c-Jun蛋白; 2.四种胰腺癌细胞系均具有不同的激活蛋白-1（AP-1）活性。提示激活蛋白-1的激活与胰腺癌肝转移有关; 3.激活AP-1的MT-21对胰腺癌细胞株的生长和侵袭能力具有剂量依赖性抑制作用; 4.未发现胰腺癌肝转移和侵袭能力与AP-1蛋白表达之间的关系。我们将进一步探讨胰腺癌与AP-1的关系。

项目成果

期刊论文数量（70）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers

DOI：
10.1016/j.surg.2005.07.007
发表时间：
2005-10-01
期刊：
SURGERY
影响因子：
3.8
作者：
Ito, Y;Okada, Y;Manabe, T
通讯作者：
Manabe, T

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.

局灶性粘附激酶的激活通过细胞外信号调节的激酶-1/2信号传导途径激活来增强胰腺癌细胞的粘附和侵袭。

DOI：
10.1186/1476-4598-4-37
发表时间：
2005-10-06
期刊：
MOLECULAR CANCER
影响因子：
37.3
作者：
Sawai, Hirozumi;Okada, Yuji;Funahashi, Hitoshi;Matsuo, Yoichi;Takahashi, Hiroki;Takeyama, Hiromitsu;Manabe, Tadao
通讯作者：
Manabe, Tadao

The role of glial cell line-derived neurotrophic factor (GDNF) and lntegrinsfor invasion and metastasis in human pancreaic cancer cells.

胶质细胞源性神经营养因子（GDNF）和整合素在人胰腺癌细胞侵袭和转移中的作用。