Evaluation of adverse effect of lung cancer cryoablation for surrounding tissue

肺癌冷冻消融术对周围组织不良影响的评价

• 批准号: 16591409
• 负责人: KAWAMURA Masafumi
• 金额: $ 2.3万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591409/
• 关键词: lung cancer; pulmonary metastatic cancer; crvoablation; 食道穿孔

As pericardial effusion separates pericardium and cardiac muscle, cardiac muscle itself seems not to be frozen. However, when treated area of the lung is nearly located to coronary artery, it is afraid that the low temperature might induce the constriction of coronary artery. Therefore, we performed an examination with porcine. Under the general anesthesia, coronary artery's blood flow was measured by electric blood flow meter. The temperature of coronary's surrounding tissue was decreased gradually near to 0℃ by cryoablation. Flow meter showed no decrease of coronary flow under this condition.Next, cryo-probe touched coronary artery directly. Cryoablation could make coronary artery and vein frozen. After thawing, flow meter indicated that the coronary flow was recovered up to the previous level. Cardiac muscle near-by coronary artery was also frozen and after sacrifice of porcine pathological examination showed death of outer half cardiac muscle due to cryoablation. However, during examination, cardiac output, heart rate, and blood pressure were preserved.

由于心包积液分离了心包和心肌，心肌本身似乎没有被冻结。然而，当肺的治疗区域靠近冠状动脉时，低温可能会引起冠状动脉狭窄。因此，我们对猪进行了检查。在全麻下，用电子血流计测量冠状动脉血流量。冷冻后冠状动脉周围组织温度逐渐下降，接近0℃。在此条件下，流量计显示冠状动脉流量无减少。冷冻消融可使冠状动脉和静脉冻结。解冻后，流量计显示冠状动脉流量恢复至先前水平。同时冷冻冠状动脉附近的心肌，处死猪后病理检查显示外半心肌因冷冻消融而死亡。然而，在检查期间，心输出量、心率和血压保持不变。

项目成果

肺がんに対する新しい治療戦 凍結療法

冷冻疗法：肺癌的新疗法

• 发表时间: 2007
• 期刊: 呼吸 26
• 作者: H.Tsubochi;Y.Sohara;et al.;川村雅文
• 通讯作者: 川村雅文

肺癌凍結融解壊死療法における術中の肺温度分布推定 肺の熱伝導シミュレータの構築

肺癌冻融坏死治疗术中肺温度分布估计肺热传导模拟器的构建

• 发表时间: 2006
• 期刊: 生体医工学 44
• 作者: Cheng-long Huang;et al.;二見光
• 通讯作者: 二見光

Development of individualized immunotherapy based on the analysis on anti-tumor antigens identified using immunological and genetic methods.

基于使用免疫学和遗传学方法鉴定的抗肿瘤抗原的分析开发个体化免疫疗法。

• 发表时间: 2007
• 期刊: Gene Therapy 2007
• 作者: S.Endo;Y.Sohara;et al.;Y.Kawakami
• 通讯作者: Y.Kawakami

Lung biopsy with a 12-gauge cutting needle is possible using an insertion sheeth in animal models.

在动物模型中使用插入片可以使用 12 号切割针进行肺活检。

• 发表时间: 2004
• 期刊: Acad Radiol 11
• 作者: Y.Izumi;M.Kawamura
• 通讯作者: M.Kawamura

Percutaneous cryoablation of small pulmonary tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates

非手术候选人在计算机断层扫描引导下局部麻醉经皮冷冻消融小肺部肿瘤

• 发表时间: 2006
• 期刊: J Thorac Cardiovasc Surg 131
• 作者: Y.Sohara;et al.;M.Kawamura
• 通讯作者: M.Kawamura