Identification of genes on cDNA microarrays for prediction of sensitivity to anticancer drugs

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To investigate genes related to sensitivity of non-small cell lung cancers (NSCLCs) to therapeutic drugs, we performed cDNA microarray analysis of 37 NSCLCs after laser-capture microdissection of cancer cells from primaru tumors resected by surgery. We compared expression data with measurements of the sensitivity of surgically resected NSCLC specimens to six anticancer drugs (docetaxel, paclitaxel, irinotecan, cisplatin, gemcitabine, and vinorelbine), as measured by the CD-DST (collagen gel droplet embedded culture drug sensitivity test) method. We found significant associations between expression levels of dozens of genes and chemosensitivity of NSCLCs in each anticancer agent.