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Analysis on the polymorphism of genotype of enzymes for detoxication in patients with infertility

不孕症患者解毒酶基因多态性分析

基本信息

批准号：
16591646
负责人：
TAKAKUWA Koichi
金额：
$ 2.24万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591646/
关键词：
infertility Enzymes for detoxication Gene polymorphism Cyp1A1 GSTs

项目摘要

The etiology of the recurrent miscarriage has not been fully elucidated, and the relationship between the genotype of enzymes for detoxication and recurrent miscarrage has recently been noted. Thus, the genotypes of enzymes for detoxication, such as cytchrome P450 (CYPIAI), glutathione-S-transferase-pai (GST-pai), GST-my, GST-theta, were analyzed in patients with infertility, who had experienced recurrent miscarriages by means of polymerase-chain reaction- restrication fragment length polymorphism (PCR-RFLP) method. The patients were sent out the questionnaires concernig history of smoking, or alchol intake. So far, 44 patients were enrolled into the study, and 30 normal fertile women, who had never experienced abortions, were also enrolled into this study.The frequency of each genotype of the enzymes was compared between the patient population and control group. The significant difference was not observed concerning CYPIAI, glutathione-S-transferase-pai (GST-pai), GST my. However, the frequency of la genotype of GST-pai was signinficantly higher in patients group compared with control population. In order to obtain definite conclusion, further investigation is considered to be mandatory, increasing the number of the patients and control population

复发性流产的病因尚未完全阐明，解毒酶基因与复发性流产之间的关系最近已被注意到。为此，采用聚合酶链式反应-限制性片段长度多态性方法对反复流产不孕症患者的细胞色素P450、谷胱甘肽-S转移酶-PAI、GST-My、GST-theta等解毒酶基因分型进行了分析。向患者发出关于吸烟史或酒精摄入量的调查问卷。到目前为止，44名患者和30名从未经历过堕胎的正常生育女性也加入了这项研究。比较了患者组和对照组中每种酶基因的频率。细胞色素PIAI、谷胱甘肽-S转移酶-PAI(GST-PAI)、GST-My无显著差异。但患者组GST-PAI基因la等位基因频率明显高于对照组。为了得到明确的结论，进一步的调查被认为是强制性的，增加了患者数量和控制人口。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

続発性習慣流産に対する免疫療法の有効性に関する検討

免疫疗法治疗继发性习惯性流产的有效性研究

DOI：
发表时间：
2004
期刊：
産婦人科の実際 53
影响因子：
0
作者：
Hirose M;Nakanishi K;Kaku S;Moro H;Hodohara K;Aotani H;Takebayashi K;Noda Y;Masaki Tamura;Shoda T;高桑好一
通讯作者：
高桑好一

Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population - Possible susceptibility of HLA-A11 and-DRB1*0403 to patient population with polycystic ovary syndrome