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Relatinoship between systemic osteoporosis and changes of alveolar trabecular structure.

系统性骨质疏松症与牙槽骨小梁结构变化的关系。

基本信息

批准号：
16591938
负责人：
TANAKA Mikako
金额：
$ 2.18万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

Purpose ; Epidemiological studies have shown that post-menopausal women who do not use an estrogen supplement have fewer teeth than those who do. And the changes of mandibular inferior cortex on the x-ray photographs has been established as the reliable diagnostic findings related to the systemic osteoporosis. However, the effect of estrogen deficiency on the alveolar structure has not been made clear. Therefore, in this research, we examined the alveolar bone structural changes on ovariectomized monkey, in order to elucidate the micro-structural changes of the mandibular alveolar bone and inferior cortex following ovariectomy.Methods ; Twelve female adult cynomorgus monkeys were used. All animal procedures were performed in accordance with institutional and NIH guidelines. The 12 animals were randomly divided into 2 groups of 6. The test group was bilaterally ovariectomized (OVX) and the remained received sham surgery (SHAM)., 76 weeks after surgery, all animals were killed, after bei … More ng anesthetized with ketamine and pentobarbital. The micro-trabecular structures of mandibular molar and canine regions and inferior cortex were histologically and bone-histomorphometrically examined, using micro CT and confocal laser scanning microscope.Results ; In the mandible of ovariectomized monkey, 1) Bone volume of canine alveolar bone decreased corresponding to the bone density of lumbar vertebra and radius. Inside the alveolar bone, alveolar proper, which is directly supporting tooth root, became thin, because the bone marrow enlarged in a direction of the alveolar proper. 2) In the OVX, the micro-structural changes such as the loss of trabecular connectivity and rod-shaped changes of trabeculae were found, however, the bone volume of second molar alveolar bone showed no significant decrease. 3) The alveolar bone changes in canine region was slightly different from those in the molar region. 4) In the mandibular cortex, osteon remodeling accelerated and large tubular structure was formed. This was considered to be the striped shadow shown on the clinical x-ray photographs. Less

目的：流行病学研究表明，没有使用雌激素补充剂的绝经后妇女的牙齿比使用雌激素补充剂的妇女少。X线片上下颌骨下皮质的改变是诊断全身性骨质疏松症的可靠依据。然而，雌激素缺乏对肺泡结构的影响尚不清楚。因此，本研究对去卵巢猕猴的牙槽骨结构变化进行了研究，以阐明去卵巢后下牙槽骨和下皮质的微结构变化。所有动物手术均按照机构和NIH指南进行。12只动物随机分为2组，每组6只。实验组切除双侧卵巢(OVX)，其余动物行假手术(Sham)，术后76周处死动物，行BEI…更多的NG用氯胺酮和戊巴比妥麻醉。采用显微CT和激光共聚焦扫描显微镜对下颌磨牙区、尖牙区和下皮质的骨小梁结构进行了组织学和骨形态计量学研究。结果：去卵巢猴下颌骨中，1)犬牙槽骨体积随腰椎和桡骨骨密度的增加而减小。在牙槽骨内部，直接支撑牙根的牙槽骨本身变薄，因为骨髓向牙槽骨本身方向增大。2)OVX组骨小梁连通性丧失，骨小梁呈杆状改变，第二磨牙牙槽骨体积无明显减少。3)尖牙区和磨牙区的牙槽骨改变略有不同。4)下颌骨皮质骨质骨改建加速，形成大管状结构。这被认为是临床X光照片上显示的条状阴影。较少